M
Miles A. Whittington
Researcher at Hull York Medical School
Publications - 216
Citations - 23413
Miles A. Whittington is an academic researcher from Hull York Medical School. The author has contributed to research in topics: Population & Hippocampal formation. The author has an hindex of 77, co-authored 212 publications receiving 21961 citations. Previous affiliations of Miles A. Whittington include University of Bristol & University of Leeds.
Papers
More filters
Journal ArticleDOI
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Journal ArticleDOI
Gamma rhythms and beta rhythms have different synchronization properties.
TL;DR: A simplified model is used to show that the different rhythms in the CA1 region of the hippocampus employ different dynamical mechanisms to synchronize, based on different ionic currents, which are consistent with data suggesting that gamma rhythms are used for relatively local computations whereas beta rhythms are use for higher level interactions involving more distant structures.
Journal ArticleDOI
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
Millan Mark,Yves Agid,Martin Brüne,Edward T. Bullmore,Cameron S. Carter,Nicola S. Clayton,Richard C. Connor,Sabrina Davis,Bill Deakin,Robert J. DeRubeis,Bruno Dubois,Mark A. Geyer,Guy M. Goodwin,Philip Gorwood,Thérèse M. Jay,Marian Joëls,Isabelle M. Mansuy,Andreas Meyer-Lindenberg,Declan G. Murphy,Edmund T. Rolls,Bernd Saletu,Michael Spedding,John A. Sweeney,Miles A. Whittington,Larry J. Young +24 more
TL;DR: This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Journal ArticleDOI
Inhibition-based rhythms: experimental and mathematical observations on network dynamics
TL;DR: This review will provide the reader with a brief outline of the basic properties of inhibition-based oscillations in the CNS by combining research from laboratory models, large-scale neuronal network simulations, and mathematical analysis.
Journal ArticleDOI
Prion protein is necessary for normal synaptic function
John Collinge,Miles A. Whittington,Katie C. L. Sidle,Corinne J. Smith,Mark S. Palmer,Anthony R. Clarke,John G. R. Jefferys +6 more
TL;DR: It is argued that loss of function of PrPc may contribute to the early synaptic loss3 and neuronal degeneration seen in Creutzfeldt–Jakob disease and scrapie and bovine spongiform encephalopathy in animals.