M
Miles R. Armstrong
Researcher at James Hutton Institute
Publications - 48
Citations - 5684
Miles R. Armstrong is an academic researcher from James Hutton Institute. The author has contributed to research in topics: Phytophthora infestans & Effector. The author has an hindex of 26, co-authored 45 publications receiving 5037 citations. Previous affiliations of Miles R. Armstrong include Seattle Children's Research Institute & University of Dundee.
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Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
A translocation signal for delivery of oomycete effector proteins into host plant cells
Stephen C. Whisson,Petra C. Boevink,Lucy N. Moleleki,Anna O. Avrova,Juan G. Morales,Eleanor M. Gilroy,Miles R. Armstrong,Severine Grouffaud,Severine Grouffaud,Pieter van West,Sean Chapman,Ingo Hein,Ian K. Toth,Leighton Pritchard,Paul R. J. Birch +14 more
TL;DR: Functional analyses of two motifs, RXLR and EER, present in translocated oomycete effectors are reported, showing that RXLR-EER-encoding genes are transcriptionally upregulated during infection and 425 potential genes encoding secreted RXLR/EER class proteins in the P. infestans genome are identified.
Journal ArticleDOI
An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm
Miles R. Armstrong,Stephen C. Whisson,Leighton Pritchard,Leighton Pritchard,Jorunn I. B. Bos,Eduard Venter,Anna O. Avrova,Anne P. Rehmany,Ulrike Böhme,Karen Brooks,Inna Cherevach,N. Hamlin,Brian White,Audrey Fraser,Angela Lord,Michael A. Quail,Carol Churcher,Neil Hall,Matthew Berriman,Sanwen Huang,Sophien Kamoun,Jim Beynon,Paul R. J. Birch +22 more
TL;DR: The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847, and it is suggested that Avr3a has undergone gene duplication and that an allele evading recognition by R3a arose under positive selection.
Journal ArticleDOI
Differential Recognition of Highly Divergent Downy Mildew Avirulence Gene Alleles by RPP1 Resistance Genes from Two Arabidopsis Lines
Anne P. Rehmany,Anna Gordon,Laura E. Rose,Rebecca L. Allen,Miles R. Armstrong,Stephen C. Whisson,Sophien Kamoun,Brett M. Tyler,Paul R. J. Birch,Jim Beynon +9 more
TL;DR: The cloning of ATR1NdWsB has highlighted the presence of a highly conserved novel amino acid motif in avirulence proteins from three different oomycetes and its similarity to a host-targeting signal from malaria parasites suggest a conserved role in pathogenicity.
Journal ArticleDOI
Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1.
Jorunn I. B. Bos,Miles R. Armstrong,Eleanor M. Gilroy,Petra C. Boevink,Ingo Hein,Rosalind M. Taylor,Rosalind M. Taylor,Tian Zhendong,Tian Zhendong,Stefan Engelhardt,Ramesh R. Vetukuri,Ramesh R. Vetukuri,Brian Harrower,Christina Dixelius,Glenn J. Bryan,Ari Sadanandom,Stephen C. Whisson,Sophien Kamoun,Paul R. J. Birch +18 more
TL;DR: The data provide genetic evidence that AVR3a is an essential virulence factor that targets and stabilizes the plant E3 ligase CMPG1, potentially to prevent host cell death during the biotrophic phase of infection.