Author
Milton M. McAllister
Other affiliations: Federal University of Bahia, Colorado State University, University of Illinois at Urbana–Champaign ...read more
Bio: Milton M. McAllister is an academic researcher from University of Adelaide. The author has contributed to research in topics: Neospora caninum & Neospora. The author has an hindex of 37, co-authored 81 publications receiving 5699 citations. Previous affiliations of Milton M. McAllister include Federal University of Bahia & Colorado State University.
Topics: Neospora caninum, Neospora, Toxoplasma gondii, Outbreak, Toxoplasmosis
Papers published on a yearly basis
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TL;DR: Dogs are a definitive host of Neospora caninum, and mice inoculated with canine faecal extracts were monitored for evidence of neosporosis using a variety of morphologic, immunohistologic, serologic, and genetic analyses.
1,069 citations
01 Jan 2004
TL;DR: In this article, four captive-raised coyote pups consumed tissues from Neospora caninum-infected calves and shed Oocysts, which tested positive for N.caninum and negative for Hammondia heydorni using PCR tests.
Abstract: Four captive-raised coyote pups consumed tissues from Neospora caninum-infected calves. Faeces were examined from 4 days before to 28 days after infection. One pup shed N. caninum-like oocysts, which tested positive for N. caninum and negative for Hammondia heydorni using PCR tests. Coyotes are the second discovered definitive host of N. caninum, after dogs. In North America, the expanding coyote ranges and population increase the probability of contact with domestic livestock. To reduce the risk of transmission of N. caninum to intensively farmed cattle, we recommend protection of feedstuffs using canid-proof fences, and careful disposal of dead stock.
523 citations
TL;DR: Four captive-raised coyote pups consumed tissues from Neospora caninum-infected calves, and one pup shed N. canInum-like oocysts, which tested positive for N.Caninum and negative for Hammondia heydorni using PCR tests.
520 citations
TL;DR: A major role for CD8 T cells in anti-tuberculosis immunity is demonstrated, and the view that CD 8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics is supported.
Abstract: The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the specificity and functions of CD8 T cells, such as the expression of group 1 CD1 proteins that are capable of presenting Mycobacterium tuberculosis lipids antigens and the cytotoxic/bactericidal protein granulysin. Employing a more relevant nonhuman primate model of human tuberculosis, we examined the contribution of BCG- or M. tuberculosis-elicited CD8 T cells to vaccine-induced immunity against tuberculosis. CD8 depletion compromised BCG vaccine-induced immune control of M. tuberculosis replication in the vaccinated rhesus macaques. Depletion of CD8 T cells in BCG-vaccinated rhesus macaques led to a significant decrease in the vaccine-induced immunity against tuberculosis. Consistently, depletion of CD8 T cells in rhesus macaques that had been previously infected with M. tuberculosis and cured by antibiotic therapy also resulted in a loss of anti-tuberculosis immunity upon M. tuberculosis re-infection. The current study demonstrates a major role for CD8 T cells in anti-tuberculosis immunity, and supports the view that CD8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics.
258 citations
United States Department of Agriculture1, University of California, Davis2, Ontario Veterinary College3, Norwegian University of Life Sciences4, Swedish University of Agricultural Sciences5, Cornell University6, Auburn University7, University of Technology, Sydney8, University of Bern9, University of Kentucky10, Obihiro University of Agriculture and Veterinary Medicine11, Academy of Sciences of the Czech Republic12, University of Veterinary and Pharmaceutical Sciences Brno13, University of Missouri14, University of Illinois at Urbana–Champaign15, Washington University in St. Louis16, University of Tennessee17, Liverpool School of Tropical Medicine18, Kansas State University19, Virginia–Maryland Regional College of Veterinary Medicine20
TL;DR: The authors redescribe the parasite, distinguish it from related coccidia, and provide accession numbers to its type specimens deposited in museums.
225 citations
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TL;DR: Dogs are a definitive host of Neospora caninum, and mice inoculated with canine faecal extracts were monitored for evidence of neosporosis using a variety of morphologic, immunohistologic, serologic, and genetic analyses.
1,069 citations
TL;DR: This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated.
Abstract: Neospora caninum is a protozoan parasite of animals. Until 1988, it was misidentified as Toxoplasma gondii. Since its first recognition in dogs in 1984 and the description of the new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. Abortions and neonatal mortality are a major problem in livestock operations, and neosporosis is a major cause of abortion in cattle. Although antibodies to N. caninum have been reported, the parasite has not been detected in human tissues. Thus, the zoonotic potential is uncertain. This review is focused mainly on the epidemiology and control of neosporosis in cattle, but worldwide seroprevalences of N. caninum in animals and humans are tabulated. The role of wildlife in the life cycle of N. caninum and strategies for the control of neosporosis in cattle are discussed.
977 citations
TL;DR: Neospora caninum is a recently recognized protozoan parasite of animals, which until 1988 was misidentified as Toxoplasma gondii, and its life cycle is unknown.
963 citations
TL;DR: Information on biology, diagnosis, epidemiology and control of neosporosis in animals, a major cause of abortion in cattle in many countries, is reviewed.
Abstract: Neospora caninum is a coccidian parasite of animals. It is a major pathogen for cattle and dogs and it occasionally causes clinical infections in horses, goats, sheep, and deer. Domestic dogs are the only known definitive hosts for N. caninum. It is one of the most efficiently transmitted parasite of cattle and up to 90% of cattle in some herds are infected. Transplacental transmission is considered the major route of transmission of N. caninum in cattle. Neospora caninum is a major cause of abortion in cattle in many countries. To elicit protective immunity against abortion in cows that already harbor a latent infection is a major problem. This paper reviews information on biology, diagnosis, epidemiology and control of neosporosis in animals.
770 citations