M
Min-Sik Kim
Researcher at Daegu Gyeongbuk Institute of Science and Technology
Publications - 159
Citations - 9078
Min-Sik Kim is an academic researcher from Daegu Gyeongbuk Institute of Science and Technology. The author has contributed to research in topics: Proteome & Proteomics. The author has an hindex of 43, co-authored 152 publications receiving 7859 citations. Previous affiliations of Min-Sik Kim include Korea University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A draft map of the human proteome
Min-Sik Kim,Sneha M. Pinto,Derese Getnet,Raja Sekhar Nirujogi,Srikanth S. Manda,Raghothama Chaerkady,Anil K. Madugundu,Dhanashree S. Kelkar,Ruth Isserlin,Shobhit Jain,Joji Kurian Thomas,Babylakshmi Muthusamy,Pamela Leal-Rojas,Pamela Leal-Rojas,Praveen Kumar,Nandini A. Sahasrabuddhe,Lavanya Balakrishnan,Jayshree Advani,Bijesh George,Santosh Renuse,Lakshmi Dhevi N. Selvan,Arun H. Patil,Vishalakshi Nanjappa,Aneesha Radhakrishnan,Samarjeet Prasad,Tejaswini Subbannayya,Rajesh Raju,Manish Kumar,Sreelakshmi K. Sreenivasamurthy,Arivusudar Marimuthu,Gajanan Sathe,Sandip Chavan,Keshava K. Datta,Yashwanth Subbannayya,Apeksha Sahu,Soujanya D. Yelamanchi,Savita Jayaram,Pavithra Rajagopalan,Jyoti Sharma,Krishna R Murthy,Nazia Syed,Renu Goel,Aafaque Ahmad Khan,Sartaj Ahmad,Gourav Dey,Keshav Mudgal,Aditi Chatterjee,Tai-Chung Huang,Jun Zhong,Xinyan Wu,Patrick G. Shaw,Donald Freed,Muhammad Saddiq Zahari,Kanchan K Mukherjee,Subramanian Shankar,Anita Mahadevan,Henry H N Lam,Chris J. Mitchell,Susarla K. Shankar,Parthasarathy Satishchandra,John T. Schroeder,Ravi Sirdeshmukh,Anirban Maitra,Steven D. Leach,Charles G. Drake,Marc K. Halushka,T. S. Keshava Prasad,Ralph H. Hruban,Candace L. Kerr,Candace L. Kerr,Gary D. Bader,Christine A. Iacobuzio-Donahue,Harsha Gowda,Akhilesh Pandey +73 more
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Journal ArticleDOI
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Aaron R. Haeusler,Christopher J. Donnelly,Goran Periz,Eric A J Simko,Patrick G. Shaw,Min-Sik Kim,Nicholas J. Maragakis,Juan C. Troncoso,Akhilesh Pandey,Rita Sattler,Jeffrey D. Rothstein,Jiou Wang +11 more
TL;DR: It is demonstrated that distinct C9orf72 HRE structural polymorphism at both DNA and RNA levels initiates molecular cascades leading to ALS/FTD pathologies, and provides the basis for a mechanistic model for repeat-associated neurodegenerative diseases.
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Hierarchical Nanostructured Carbons with Meso–Macroporosity: Design, Characterization, and Applications
TL;DR: In this article, a hierarchical nanostructured carbon (HNC) with macroporous/mesoporous and mesoporous/microporous structures has been proposed, which has improved mass transport through the macropores/meso-pores and enhanced selectivity and increased specific surface area on the level of fine pore systems through mesopores ormicropores.
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Homogeneous deposition of platinum nanoparticles on carbon black for proton exchange membrane fuel cell.
TL;DR: The Pt NPs deposited on Vulcan XC-72 (VC) carbon black by the HD-EG strategy show smaller size with more uniform dispersion, higher Pt utilization efficiency, and considerably improved fuel-cell polarization performance compared with the Pt NBP prepared by conventional sodium borohydride reduction or by a microwave-assisted polyol approach.
Journal ArticleDOI
Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
Ian Martin,Jungwoo Wren Kim,Byoung Dae Lee,Ho Chul Kang,Jinchong Xu,Hao Jia,Jeannette N. Stankowski,Min-Sik Kim,Jun Zhong,Manoj Kumar,Shaida A. Andrabi,Yulan Xiong,Dennis W. Dickson,Zbigniew K. Wszolek,Akhilesh Pandey,Ted M. Dawson,Valina L. Dawson +16 more
TL;DR: It is shown that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron PD models and can be prevented by phosphodeficient T136A s15, revealing a novel mechanism of PD pathogenesis linked to elevated L RRK2 kinase activity and aberrant protein synthesis in vivo.