Showing papers by "Min Xu published in 2013"
TL;DR: Six new bisbenzylisoquinoline alkaloids (1-6) and seven known compounds (8-14) were isolated from the tubers of Stephania epigaea, in addition to the major alkaloid, cepharanthine, which exhibited cytotoxicity against all six cancer cell lines except ECA109.
Abstract: Six new bisberizylisoquinoline alkaloids (1-6) and seven known compounds (8-14) were isolated from the tubers of Stephania epigaea, in addition to the major alkaloid, cepharanthine (7). The structures of 1-6 were elucidated by combined spectroscopic data analysis and chemical methods, with their configurations determined from their optical rotation values and confirmed using circular dichroism. Compounds 1-6 belong to the oxyacanthine type of bisbenzylisoquinoline alkaloids and have a rare methylenedioxy substituent. Compound 1, a dimer composed of benzylisoquinoline and seco-aristolactam units, represents a new type of bisbenzylisoquinoline alkaloid, while compounds 306 are bisbenzylisoquinoline N-oxides. These compounds were evaluated for their in vitro cytotoxicities against six human cancer cell lines (A-549, ECA109, HL-60, MCF-7, SMMC-7721, and SW480). Cepharanthine (7), the major component of S. epigaea, exhibited cytotoxicity against all of these cancer cell lines except ECA109, while its known analogue, 10, displayed cytotoxicity against all six cancer cell lines.
37 citations
TL;DR: The results support the historical importance of the well-known TCM herb, "Qin-Jiao", having been commonly used for fighting RA, and the bioactive iridoid glycosides should play important role in the anti-inflammatory effect of "Zebrafish".
37 citations
TL;DR: Statistic analysis of correlation between morphologic variation and chemical variation suggests that some morphological characters, such as root weight, plant height and peduncle length, can be correlated with saponin contents and can be used as important selective traits for selective breeding.
23 citations
TL;DR: In this article, three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus.
21 citations
TL;DR: A new 6/6/5/6-fused limonoid, phyllanthoid A, possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis and displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.
20 citations
TL;DR: Three new acylated flavonoid C-glycosides were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae) by means of spectroscopic analysis and chemical method.
Abstract: Three new acylated flavonoid C-glycosides, 6‴-(-)-phaseoylspinosin (1), 6‴-(3″″,4″″,5″″-trimethoxyl)-(E)-cinnamoylspinosin (2), and 6‴-(4″″-O-β-D-gluco-pyranosyl)-benzoylspinosin (3), were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae). A further 19 known compounds including eight spinosin analogues (4–11) were also isolated. Their structures were elucidated by means of spectroscopic analysis and chemical method. Among spinosin derivatives 1, 2, 4, 7, 8, and triterpenoid saponin 14, jujuboside A (14) displayed moderate acetylcholinesterase (AchE) inhibitory activity with an inhibition value of 46.2% at a concentration of 1 µM.
7 citations
TL;DR: Five new sucrose benzoyl esters are isolated from the whole plants of Phyllanthus cochinchinensis on the basis of detailed spectroscopic analysis and chemical method.
Abstract: Chemical investigation of the whole plants of Phyllanthus cochinchinensis (Euphorbiaceae) led to the isolation of five new sucrose benzoyl esters, 3,6′-di-O-benzoylsucrose (1), 3,6′-di-O-benzoyl-2′-O-acetylsucrose (2), 3,6′-di-O-benzoyl-4′-Oacetylsucrose (3), 3,6′-di-O-benzoyl-3′-O-acetylsucrose (4) and 3-O-benzoyl-6′-O-(E)-cinnamoylsucrose (5), together with two known secoiridoid glycosides, jasminoside (6) and jaslanceoside B (7). Their structures were established on the basis of detailed spectroscopic analysis and chemical method.
3 citations
Patent•
21 Aug 2013
TL;DR: In this article, an arbutin sugar ester derivative represented by a general formula I, a drug composition adopting the ARBES derivative as an active component, and an application of the ARBSE derivative in preparation of skin whitening and spot removing cosmetics or drugs for skin Whitening and pigmentation disease treatment.
Abstract: The invention relates to an arbutin sugar ester derivative represented by a general formula I, a drug composition adopting the arbutin sugar ester derivative as an active component, and an application of the arbutin sugar ester derivative in preparation of skin whitening and spot removing cosmetics or drugs for skin whitening and pigmentation disease treatment. According to the present invention, with the arbutin sugar ester derivative, melanin can be effectively inhibited and decomposed so as to completely remove melanin spots and provide effects of whitening and spot removing; acute zebrafish toxicity test results show that the arbutin sugar ester derivative has characteristics of low toxicity, high activity, efficiency and safety compared with arbutin; and in the general formula I, R represents straight chain or branched chain saturated or unsaturated alkyl acyl, or trans or cis unsaturated aromatic acyl, R1 represents hydrogen atom, or straight chain or branched chain saturated or unsaturated alkyl acyl, or trans or cis unsaturated aromatic acyl, and R2 represents hydrogen atom, and/or hydroxy or methoxy or substituted acyl.
2 citations
Patent•
29 May 2013
TL;DR: The 6'-O-caffeoyl-arbutin can effectively inhibit and decompose melanin, thoroughly remove the melanin freckles, and have the effect of whitening skin and removing freckle as mentioned in this paper.
Abstract: The invention relates to new application of 6'-O-caffeoyl-arbutin in the technical field of medicines for inhibiting melanin, particularly application of 6'-O-caffeoyl-arbutin or derivatives thereof, or a natural, synthetic or semisynthetic mixture containing the 6'-O-caffeoyl-arbutin, or a composition containing the 6'-O-caffeoyl-arbutin in preparing cosmetics for whitening skin and removing freckles or medicines for whitening skin and treating chromatodermatosis The 6'-O-caffeoyl-arbutin can effectively inhibit and decompose melanin, thoroughly remove the melanin freckles, and have the effect of whitening skin and removing freckles; and the zebra fish acute toxicity test indicates that compared with arbutin, the 6'-O-caffeoyl-arbutin has the characteristics of lower toxicity, higher activity, higher efficiency and higher safety
1 citations
TL;DR: In this paper, three new diterpenoids -phyllanflexoids A-C (I), (II), and (III) -were isolated from roots of Phyllanthus flexuosus.
Abstract: Three new diterpenoids - phyllanflexoids A-C (I), (II), and (III) - are isolated from roots of Phyllanthus flexuosus.