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Min Xu

Bio: Min Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Panax notoginseng & Medicine. The author has an hindex of 25, co-authored 122 publications receiving 1832 citations. Previous affiliations of Min Xu include Nanjing Normal University & Griffith University.


Papers
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Journal ArticleDOI
TL;DR: A detailed chemical investigation of the red resins from Dracaena cochinchinensis (Chinese dragon's blood) yielded five new flavonoid oligomers, named Cochinchinenins D-H (1−5), together with a known biflavonoid, cinnabarone (6), and a mixture of socotrin-4′-ol (7) and homoisosocotrin (4−5) as mentioned in this paper.
Abstract: A detailed chemical investigation of the red resins from Dracaena cochinchinensis (Chinese dragon’s blood) yielded five new flavonoid oligomers, named cochinchinenins D-H (1–5), together with a known biflavonoid, cinnabarone (6), and a mixture of two known biflavonoids, socotrin-4′-ol (7) and homoisosocotrin-4′-ol (8). Of these new compounds, 1–3 were biflavonoids and 4 and 5 were triflavonoids. Their structures were determined on the basis of spectroscopic analysis. The isolated compounds were tested for cytotoxicity (Cdc25), antibacterial (PEPT) and antifungal (YNG) activities. Open image in new window

21 citations

Journal ArticleDOI
TL;DR: In this article, three structurally interesting new diterpenoids, phyllanflexoids A-C(1-3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus.

21 citations

Journal ArticleDOI
TL;DR: A new 6/6/5/6-fused limonoid, phyllanthoid A, possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis and displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.

20 citations

Journal ArticleDOI
TL;DR: Sixty-three amide alkaloids, including three new, piperflaviflorine A, p Piper flaviflorum and Piper sarmentosum, and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial
Abstract: Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine (3) and N-[7′-(4′-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectroscopic analysis and, in case of 3, by single-crystal X-ray diffraction. Most of the isolates were tested for their antifungal and antibacterial activities. Ten amides (6–15) showed antifungal activity against Cryptococcus neoformans ATCC 90 113 with IC50 values in the range between 4.7 and 20.0 µg/mL.

19 citations

Journal ArticleDOI
TL;DR: The studies described here were directed at identifying metabolically robust agents with high selectivity towards SGLT2, and showed that retention of a chlorine substituent at the 4’-position on the proximal phenyl ring is critical for activity.
Abstract: Diabetes is a highly prevalent modern disease with over 246 million people afflicted worldwide in 2007. A failure of glycemic homeostasis secondary to nutritional imbalance is considered to be the principle explanation for the alarming and increasing incidence of type 2 diabetes mellitus (DM2) in both developed and developing countries. Although a large number of antihyperglycemic agents have been developed to treat the disease, 63 % of DM2 patients fail to achieve the target levels of glycosylated hemoglobin (HbA1C<7 %) recommended by the American Diabetes Association, 4] and consequently these individuals are at risk of developing complications, such as accelerated cardiovascular disease, diabetic nephropathy, retinopathy and ulceration. Recently, renewed emphasis on the development of safe oral antidiabetic agents with a favorable cardiovascular profile has highlighted the attractions of inhibition of renal glucose resorption as a therapeutic mechanism. Sodium glucose co-transporter 2 (SGLT2) is a 672-amino acid, high-capacity, low-affinity transporter expressed nearly exclusively in the S1 and S2 segments of the renal proximal tubule and believed to mediate the majority of renal glucose resorption from the glomerular filtrate. Because the etiology of type 2 diabetes mellitus (DM2) depends on a hypertrophic adipose reservoir, mechanisms that promote glucose disposal by urinary output are therapeutically attractive compared to mechanisms that promote increased glucose assimilation by adipocytes. Selective inhibitors of SGLT2 are expected to be safe because individuals homozygous or compound heterozygous for mutations in SLC5A2, the gene encoding SGLT2, exhibit no significant morbidities. In contrast, penetrant alleles leading to SGLT1 deficiency are the genetic cause of glucose– galactose malabsorption syndrome, which is associated with severe neonatal diarrhea and failure to thrive. In particular, the high selectivity could potentially reduce the gastrointestinal side effect. Hence inhibitors selective for SGLT2 over SGLT1 are attractive candidates for development. Following the initial disclosure of T-1095A, a selective and potent SGLT2 inhibitor designed based on the naturally occurring inhibitor phlorizin, by Tanabe Seiyaku Co., Ltd. (Osaka, Japan), multiple classes of SGLT2 inhibitors have been reported, including Oand C-glucosides. The most advanced inhibitors currently undergoing clinical development in phase III trials, dapagliflozin (1) 16] and canagliflozin, are C-arylglucosides. The studies described here were directed at identifying metabolically robust agents with high selectivity towards SGLT2. Information gained from modeling studies and analysis of the crystal structure of dapagliflozin (1) suggested the possibility of creating novel and conformationally constrained chemotypes with improved potency for SGLT2 by cyclizing the 1and 6’-positions of the glucose moiety and glucose-proximal phenyl ring (Figure 1). Preliminary studies showed that retention of a chlorine substituent at the 4’-position on the proximal phenyl ring is critical for activity. The synthesis and evaluation of three series of novel analogues, which have a different scaffold than previously reported inhibitors, are described here. The synthesis of spiro[isobenzofuran-1,2’-pyran] analogues 12 a–e was addressed first (Scheme 1). Persilylated gluconolactone 3 was prepared in 89 % yield by the slow addition of trimethylsilyl chloride (TMSCl) to commercially available gluconolactone 2 in the presence of N-methylmorpholine. 21] Benzoic acid 4 was subjected to bromination with N-bromosuccinimide (NBS) followed by esterification to yield aniline 6. Sandmeyer reaction and subsequent oxidation of 7 provided the key electron-deficient tetra-substituted benzene 8. Friedel–Crafts acylation of R substituted benzenes generated the benzophenone 9. Selective reduction of the resulting ketone with triethylsilane and further reduction of the methyl ester gave the corresponding benzyl alcohol 10. Protection of the primary hydroxy group with chloromethyl methyl ether produced bromide 11. Lithium–halogen exchange and subsequent coupling with lactone 3 gave a mixture of lactols, which were converted in situ to the desired spiro[isobenzofuran-1,2’-pyran] derivatives 12 a–e in 40 to 63 % yield after purification by preparative thin layer chromatography (TLC). The synthesis of spiro[indane-1,2’-pyran] glucosides 19 a–e was more challenging than that of O-spiroketal C-arylglucosides analogues (Scheme 2). Benzyl alcohol 13 was oxidized with Dess–Martin reagent and subsequently subjected to [a] B. Lv, B. Xu, Prof. Dr. Y. Chen Chengdu Institute of Organic Chemistry (CIOC) Chinese Academy of Sciences (CAS) No. 16, Southion 2, the first circle road, 610041 Chengdu (P.R. China) Fax: (+ 86) 28-8525-9387 E-mail : 51popo51@163.com chenyw@cioc.ac.cn [b] B. Lv, Dr. Y. Feng, Dr. J. Dong, Dr. M. Xu, B. Xu, W. Zhang, Dr. Z. Sheng, Prof. Dr. Y. Chen Egret Pharma (Shanghai) Company, Ltd. Halei Road 1118, 201203 Shanghai (P.R. China) [c] Dr. A. Welihinda, Prof. Dr. B. Seed Theracos Inc. , 550 Del Rey Avenue, Sunnyvale, CA 94805-3528 (USA) Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/cmdc.201000051.

19 citations


Cited by
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Journal ArticleDOI
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.

4,649 citations

Journal ArticleDOI
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.

1,728 citations

01 Dec 2013
TL;DR: This paper found that the most intensive glacier shrinkage is in the Himalayan region, whereas glacial retreat in the Pamir Plateau region is less apparent, due to changes in atmospheric circulations and precipitation patterns.
Abstract: Glacial melting in the Tibetan Plateau affects the water resources of millions of people. This study finds that—partly owing to changes in atmospheric circulations and precipitation patterns—the most intensive glacier shrinkage is in the Himalayan region, whereas glacial retreat in the Pamir Plateau region is less apparent.

1,599 citations

01 Dec 2007

1,121 citations