Author
Min Xu
Other affiliations: Nanjing Normal University, Griffith University
Bio: Min Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Panax notoginseng & Medicine. The author has an hindex of 25, co-authored 122 publications receiving 1832 citations. Previous affiliations of Min Xu include Nanjing Normal University & Griffith University.
Topics: Panax notoginseng, Medicine, Glacier, Glacier mass balance, Theaceae
Papers published on a yearly basis
Papers
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TL;DR: Two new highly oxygenated limonoids, flexuosoids A and B (2) showed promising antifeedant activity against the beet army worm (Spodoptera exigua) and moderate cytotoxicity against the ECA109 human esophagus cancer cell line, along with the known lignan glycoside, phyllanthusmin C.
Abstract: Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D–F (3–5), were isolated from the roots of Phyllanthus flexuosus, in addition to three known lignans, phyllanthusmin C, arabelline, and (+)-diasyringaresinol. Their structures were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1 and 2, two new decaoxygenated limonoids with a C-19/29 lactol bridge and heptaoxygenated substituents at C-1, C-2, C-3, C-7, C-11, C-17, and C-30, represent the second example of limonoids in the Euphorbiaceae family. Most of the isolates were tested for their antifeedant, anti-herpes simplex virus 1, and cytotoxic activities. The new limonoids 1 and 2 showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3 μg/cm2, respectively. In addition, both of them displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, along with the known lignan glycoside, phyllanthusmin C, with the IC50 values of 11.5 (1), 8.5 (2), and 7.8 (phyllanthusmin C) μM, respectively. Two new highly oxygenated limonoids, flexuosoids A (1) and B (2), and three new arylnaphthalene lignan glycosides, phyllanthusmins D–F (3–5), were isolated from the roots of Phyllanthus flexuosus, along with three known lignans. Flexuosoids A (1) and B (2) showed promising antifeedant activity against the beet army worm (Spodoptera exigua) with EC50 values of 25.1 and 17.3 μg/cm2, respectively. In addition, both of them and the known lignan glycoside, phyllanthusmin C, displayed moderate cytotoxicity against the ECA109 human esophagus cancer cell line, with the IC50 values of 11.5, 8.5, and 7.8 μM, respectively.
12 citations
TL;DR: In this paper, four new patchoulol derivatives, 8 alpha, 9 alpha-dihydroxypatchoulol (1), 3 alpha,8 alpha-Dihd-RH, 6 alpha-HOG, and 2 beta,12-DRH, were isolated from the aerial part of Pogostemon cablin (Labiatae), together with nine known compounds, sesquiterpenoids 5-8 and flavonoids 9-13.
Abstract: Four new patchoulol derivatives, 8 alpha,9 alpha-dihydroxypatchoulol (1), 3 alpha,8 alpha-dihydroxypatchoulol (2), 6 alpha-hydroxypatchoulol (3), and 2 beta,12-dihydroxypatchoulol (4), were isolated from the aerial part of Pogostemon cablin (Labiatae), together with nine known compounds, sesquiterpenoids 5-8 and flavonoids 9-13. Their structures were elucidated by detailed spectroscopic analysis, using 1D- and 2D-NMR techniques.
12 citations
TL;DR: Further phytochemical investigation of the steaming treated roots of Panax notoginseng (Araliaceae) led to the identification of two new dammarane-type triterpenoid saponins, notoginenoside SP20 and SP21, which showed no in vitro cytotoxicity against five human cancer cell lines.
12 citations
TL;DR: The accumulation of saponins showed a time-dependent increase after germination of P. notoginseng roots during germination and juvenile stage and in the five-month-old root, all these five main saponin came into existence.
Abstract: Background: Panax notoginseng is an important Chinese medicinal plant. Dammarene-type triterpenoid saponins are main pharmacologically effective compounds in P. notoginseng. This study aims to investigate the formation and accumulation of saponins in P. notoginseng roots during germination and juvenile stage. Methods: P. notoginseng seeds were collected and stored in wet sand. After germination, the seedlings were transplanted into a soil nursery bed and cultivated for one year. During this period, samples were collected every month and the concentrations of ginsengnosides Rg1, Re, Rb1, Rd and notoginsengnoside R1 were determined by HPLC. Results: There was little saponin in the P. notoginseng seed. The chemical composition of seed was different from that of root. After germination, Rb1 ,R g1, Re, Rd and R1 appeared successively in the seedling root. And in the fivemonth-old root, all these five main saponins came into existence. The accumulation of saponins in P. notoginseng root was affected by seasons. Conclusion: The accumulation of saponins showed a time-dependent increase after germination of P. notoginseng.
11 citations
TL;DR: Wang et al. as discussed by the authors used the Kernel Density (DE) and spatial mean center of SWPI transfer curve to explore the characteristics with the dataset of 1174 cases from 2006 to 2018 in China.
10 citations
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TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
TL;DR: This review summarizes the chemistry, biosynthesis and occurrence of the compounds involved, namely the C6-C3-C6 flavonoids-anthocyanins, dihydrochalcones, Flavan-3-ols, flavanones, flavones, Flavonols and isoflavones, and the mechanisms underlying these processes are discussed.
1,728 citations
01 Dec 2013
TL;DR: This paper found that the most intensive glacier shrinkage is in the Himalayan region, whereas glacial retreat in the Pamir Plateau region is less apparent, due to changes in atmospheric circulations and precipitation patterns.
Abstract: Glacial melting in the Tibetan Plateau affects the water resources of millions of people. This study finds that—partly owing to changes in atmospheric circulations and precipitation patterns—the most intensive glacier shrinkage is in the Himalayan region, whereas glacial retreat in the Pamir Plateau region is less apparent.
1,599 citations
1,326 citations