Minerva E. Sanchez

TL;DR: The Encyclopedia of DNA Elements project provides new insights into the organization and regulation of the authors' genes and genome, and is an expansive resource of functional annotations for biomedical research.

TL;DR: The first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types is presented, revealing novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns.

TL;DR: An overview of the project and the resources it is generating and the application of ENCODE data to interpret the human genome are provided.

TL;DR: Next generation editing approaches provide a promising new modality for treating patients with Beta thalassemia and SCD, and the most effective nucleotide residue conversions are supported by natural variation seen in patients with hereditary persistence of fetal hemoglobin (HPFH).

TL;DR: Ex vivo erythroid cultures suggests BCL11A erystroid-enhancer editing may lead to slightly increased apoptosis during eryhroid differentiation, and reduced editing levels at BCL 11A ERYthroid-specific enhancer in the erytroid compartment compared to unfractionated bone marrow (BM) or other human lineages.