M
Ming T. Tsuang
Researcher at University of California, San Diego
Publications - 917
Citations - 80789
Ming T. Tsuang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Schizophrenia & Psychosis. The author has an hindex of 140, co-authored 885 publications receiving 73865 citations. Previous affiliations of Ming T. Tsuang include University of California, Irvine & Washington University in St. Louis.
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Journal ArticleDOI
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek,Konrad J. Karczewski,Konrad J. Karczewski,Eric Vallabh Minikel,Eric Vallabh Minikel,Kaitlin E. Samocha,Eric Banks,Timothy Fennell,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,James S. Ware,Andrew J. Hill,Andrew J. Hill,Andrew J. Hill,Beryl B. Cummings,Beryl B. Cummings,Taru Tukiainen,Taru Tukiainen,Daniel P. Birnbaum,Jack A. Kosmicki,Laramie E. Duncan,Laramie E. Duncan,Karol Estrada,Karol Estrada,Fengmei Zhao,Fengmei Zhao,James Zou,Emma Pierce-Hoffman,Emma Pierce-Hoffman,Joanne Berghout,David Neil Cooper,Nicole A. Deflaux,Mark A. DePristo,Ron Do,Jason Flannick,Jason Flannick,Menachem Fromer,Laura D. Gauthier,Jackie Goldstein,Jackie Goldstein,Namrata Gupta,Daniel P. Howrigan,Daniel P. Howrigan,Adam Kiezun,Mitja I. Kurki,Mitja I. Kurki,Ami Levy Moonshine,Pradeep Natarajan,Lorena Orozco,Gina M. Peloso,Gina M. Peloso,Ryan Poplin,Manuel A. Rivas,Valentin Ruano-Rubio,Samuel A. Rose,Douglas M. Ruderfer,Khalid Shakir,Peter D. Stenson,Christine Stevens,Brett Thomas,Brett Thomas,Grace Tiao,María Teresa Tusié-Luna,Ben Weisburd,Hong-Hee Won,Dongmei Yu,David Altshuler,David Altshuler,Diego Ardissino,Michael Boehnke,John Danesh,Stacey Donnelly,Roberto Elosua,Jose C. Florez,Jose C. Florez,Stacey Gabriel,Gad Getz,Gad Getz,Stephen J. Glatt,Christina M. Hultman,Sekar Kathiresan,Markku Laakso,Steven A. McCarroll,Steven A. McCarroll,Mark I. McCarthy,Mark I. McCarthy,Dermot P.B. McGovern,Ruth McPherson,Benjamin M. Neale,Benjamin M. Neale,Aarno Palotie,Shaun Purcell,Danish Saleheen,Jeremiah M. Scharf,Pamela Sklar,Patrick F. Sullivan,Patrick F. Sullivan,Jaakko Tuomilehto,Ming T. Tsuang,Hugh Watkins,Hugh Watkins,James G. Wilson,Mark J. Daly,Mark J. Daly,Daniel G. MacArthur,Daniel G. MacArthur +106 more
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Journal ArticleDOI
Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
Susan Whitfield-Gabrieli,Heidi W. Thermenos,Snezana Milanovic,Ming T. Tsuang,Stephen V. Faraone,Robert W. McCarley,Martha E. Shenton,Alan I. Green,Alfonso Nieto-Castanon,Peter S. LaViolette,Joanne Wojcik,John D. E. Gabrieli,Larry J. Seidman +12 more
TL;DR: Among patients, the magnitude of MPFC task suppression negatively correlated with default connectivity, suggesting an association between the hyperactivation and hyperconnectivity in schizophrenia.
Journal ArticleDOI
Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America.
Tyrone D. Cannon,Kristin S. Cadenhead,Barbara A. Cornblatt,Scott W. Woods,Jean Addington,Elaine F. Walker,Larry J. Seidman,Diana O. Perkins,Ming T. Tsuang,Thomas H. McGlashan,Robert K. Heinssen +10 more
TL;DR: These findings demonstrate that prospective ascertainment of individuals at risk for psychosis is feasible, with a level of predictive accuracy comparable to that in other areas of preventive medicine.
Journal ArticleDOI
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Cathryn M. Lewis,Douglas F. Levinson,Lesley H. Wise,Lynn E. DeLisi,Richard E. Straub,Iiris Hovatta,Nigel Williams,Sibylle G. Schwab,Ann E. Pulver,Stephen V. Faraone,Linda M. Brzustowicz,Linda M. Brzustowicz,Charles A. Kaufmann,David L. Garver,Hugh Gurling,Eva Lindholm,Hilary Coon,Hans W. Moises,William Byerley,Sarah H. Shaw,Andrea Mesén,Robin Sherrington,F. Anthony O'Neill,Dermot Walsh,Kenneth S. Kendler,Jesper Ekelund,Tiina Paunio,Jouko Lönnqvist,Leena Peltonen,Leena Peltonen,Michael Conlon O'Donovan,Michael John Owen,Dieter B. Wildenauer,Wolfgang Maier,Gerald Nestadt,Jean-Louis Blouin,Stylianos E. Antonarakis,Bryan J. Mowry,Jeremy M. Silverman,Raymond R. Crowe,C. Robert Cloninger,Ming T. Tsuang,Dolores Malaspina,Jill M. Harkavy-Friedman,Dragan M. Svrakic,Anne S. Bassett,Jennifer A. Holcomb,Gursharan Kalsi,Andrew McQuillin,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Elena Jazin,Tómas Zoega,Tómas Helgason +54 more
TL;DR: The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
Journal ArticleDOI
Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness
Matthew S. Panizzon,Christine Fennema-Notestine,Lisa T. Eyler,Terry L. Jernigan,Elizabeth Prom-Wormley,Michael C. Neale,Kristen C. Jacobson,Michael J. Lyons,Michael D. Grant,Carol E. Franz,Hong Xian,Ming T. Tsuang,Ming T. Tsuang,Bruce Fischl,Larry J. Seidman,Anders M. Dale,William S. Kremen,William S. Kremen +17 more
TL;DR: It is demonstrated that cortical volume measures combine at least 2 distinct sources of genetic influences, and using volume in a genetically informative study, or as an endophenotype for a disorder, may confound the underlying genetic architecture of brain structure.