Author
Ming-Wu Ding
Other affiliations: China Three Gorges University
Bio: Ming-Wu Ding is an academic researcher from Central China Normal University. The author has contributed to research in topics: Wittig reaction & Triphenylphosphine. The author has an hindex of 22, co-authored 227 publications receiving 1819 citations. Previous affiliations of Ming-Wu Ding include China Three Gorges University.
Papers published on a yearly basis
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TL;DR: The bis(carbodiimides) 4, obtained from bis-aza-Wittig reactions of bis(iminophosphorane) 3 with 2 equiv of aromatic isocyanates, were reacted with secondary amine to give symmetrically substituted 2,7-diaminothieno-4,5(3H,6H)-dione 6 in the presence of a catalytic amount of EtO(-)Na(+).
Abstract: The bis(carbodiimides) 4, obtained from bis-aza-Wittig reactions of bis(iminophosphorane) 3 with 2 equiv of aromatic isocyanates, were reacted with secondary amine to give symmetrically substituted 2,7-diaminothieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-dione 6 in the presence of a catalytic amount of EtO(-)Na(+). Reactions of 4 with phenols or ROH in the presence of a catalytic amount of potassium carbonate or RO(-)Na(+) gave symmetrically substituted 2,7-diaryl(alkyl)oxythieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-diones 6 in satisfactory yields. However, iminophosphoranes 9 were obtained via reaction of bis(iminophosphorane) 3 with 1 equiv of aromatic isocyanate and subsequent reaction with an amine in the presence of a catalytic amount of EtO(-)Na(+). Further reaction of iminophosphoranes 9 with aromatic isocyanates and various nucleophile generated unsymmetrically substituted thieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-diones 12 in good yields.
109 citations
TL;DR: In this article, the aza-Wittig reaction of anhydride and the catalytic anhydric reaction of acid anoxide were both developed with high yields, which provided an efficient method to synthesize 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones.
Abstract: Compared to the aza-Wittig reaction of aldehydes, ketones, amides, and esters, the aza-Wittig reaction of acid anhydride was always overlooked, which should be an important part of Wittig reactions. Here, the aza-Wittig reaction of anhydride and catalytic aza-Wittig reaction of anhydride were both developed with high yields, which provides an efficient method to synthesize of 4H-benzo[d][1,3]oxazin-4-ones and 4-benzylidene-2-aryloxazol-5(4H)-ones. The strategy of copper-catalyzed reduction of phosphine oxide was used and found effective for this transformation. Additionally, the one-pot catalytic aza-Wittig reaction of carboxylic acids was achieved. Furthermore, NMR experiments and Hammett plot recorded the process of catalytic aza-Wittig reaction of anhydride, which provides direct proof that the copper-catalyzed reduction of waste phosphine oxide is the key step in this transformation.
92 citations
TL;DR: In this paper, the synthesis of the drug methaqualone (IVb) and the natural product deoxyvasicinone (Xa) was used as the key step in the preparation of the alkaloid (S)-vasicine.
Abstract: Besides for the synthesis of the drug methaqualone (IVb) and the natural product deoxyvasicinone (Xa) the method is used as the key step in the preparation of the alkaloid (S)-vasicinone.
55 citations
TL;DR: Carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aryl isocyanates, reacted with secondary amines in the presence of a catalytic amount of sodium alkoxide to give 1,2,4,5-tetrasubstituted imidazoles 7 in good yields.
Abstract: Carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aryl isocyanates, reacted with secondary amines in the presence of a catalytic amount of sodium alkoxide to give 1,2,4,5-tetrasubstituted imidazoles 7 in good yields. However, 4-acylimidazoles 11 were obtained, as phenols were used in the presence of a catalytic amount of potassium carbonate due to further air oxidation of the expected products 10.
52 citations
TL;DR: A series of 2,3,4-trisubstituted 3,4dihydroquinazoline 3 was prepared by intramolecular aza-Wittig reaction of amide carbonyl groups with methyldiphenyl iminophosphorane, which was obtained from a Ugi 4CC/Staudinger sequence.
51 citations
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TL;DR: Dithieno[3,2-b:2′3′-d]thiophene-4,4-dioxides 1221 3.3.1.
Abstract: 3.2. Thienothiophenes 1216 3.2.1. Thieno[3,4-b]thiophene Analogues 1216 3.2.2. Thieno[3,2-b]thiophene Analogues 1217 3.2.3. Thieno[2,3-b]thiophene Analogues 1218 3.3. , ′-Bridged Bithiophenes 1219 3.3.1. Dithienothiophene (DTT) Analogues 1220 3.3.2. Dithieno[3,2-b:2′3′-d]thiophene-4,4-dioxides 1221 3.3.3. Dithienosilole (DTS) Analogues 1221 3.3.4. Cyclopentadithiophene (CPDT) Analogues 1221 3.3.5. Nitrogen and Phosphor Atom Bridged Bithiophenes 1222
1,224 citations
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360 citations
TL;DR: Recent advances in the aza-Wittig reaction of phosphazene derivatives with several carbonyl compounds are reviewed in this article, where the most important applications of this reaction are the synthesis of a wide range of acyclic and heterocyclic compounds, ranging from simple moncyclic compounds to complex polycyclic and macrocyclic systems.
308 citations
TL;DR: In this paper, the authors present a review of recent developments in the history of theYDANTOIN CHEMISTRY, focusing on the use of chemical compounds in the production of synthetic drugs.
197 citations