Ming Yang

TL;DR: This work revealed unique features in transcriptional machinery, transcription factor networks, and reciprocal interactions in human oocytes and GCs that displayed developmental-stage-specific expression patterns and identified specific gene signatures of two cell types in particular developmental stage that may reflect developmental competency and ovarian reserve.

TL;DR: Assessment of the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio.

TL;DR: Insight is provided into the transcriptional landscape of human pituitary development, defining distinct cell substates and subtypes and illustrating transcription factor dynamics during cell fate commitment.

TL;DR: In this paper, a single-cell multi-omics sequencing technology (scNOMeRe-seq) was developed that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell.

TL;DR: A single-cell multiomics sequencing technology (scNOMeRe-seq) is developed that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the same individual cell with improved performance compared to that of earlier techniques and depicts the first single- cell triple-omics map of chromatin accessible, DNAmethylation andRNA expression during mouse preimplantation development.