M
Ming Zhan
Researcher at Cornell University
Publications - 51
Citations - 5311
Ming Zhan is an academic researcher from Cornell University. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 32, co-authored 50 publications receiving 4729 citations. Previous affiliations of Ming Zhan include National Institutes of Health & University of Maryland Marlene and Stewart Greenebaum Cancer Center.
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Journal ArticleDOI
LincRNA-p21 Suppresses Target mRNA Translation
Je Hyun Yoon,Kotb Abdelmohsen,Subramanya Srikantan,Xiaoling Yang,Jennifer L. Martindale,Supriyo De,Maite Huarte,Ming Zhan,Kevin G. Becker,Myriam Gorospe +9 more
TL;DR: It is proposed that HuR controls translation of a subset of target mRNAs by influencing lincRNA-p21 levels, which in turn derepressed JunB and β-catenin translation and increased the levels of these proteins.
Journal ArticleDOI
Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts
Suling Liu,Yang Cong,Dong Wang,Yu-Min Sun,Lu Deng,Yajing Liu,Rachel Martin-Trevino,Li Shang,Sean P. McDermott,Melissa D. Landis,Su-Hyung Hong,April Adams,Rosemarie C. D'Angelo,Christophe Ginestier,Emmanuelle Charafe-Jauffret,Shawn G. Clouthier,Daniel Birnbaum,Stephen T. C. Wong,Ming Zhan,Jenny C. Chang,Max S. Wicha +20 more
TL;DR: It is proposed that the plasticity of BCSCs that allows them to transition between EMT- and MET-like states endows these cells with the capacity for tissue invasion, dissemination, and growth at metastatic sites.
Journal ArticleDOI
Identification of a target RNA motif for RNA-binding protein HuR
TL;DR: The identification of a 17- to 20-base-long RNA motif rich in uracils allowed the successful prediction and subsequent validation of novel HuR targets from gene databases and presents a general strategy for identifying target motifs for RNA-binding proteins.
Journal ArticleDOI
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.
Isabel López de Silanes,Stefanie Galbán,Jennifer L. Martindale,Xiaoling Yang,Krystyna Mazan-Mamczarz,Fred E. Indig,Geppino Falco,Ming Zhan,Myriam Gorospe +8 more
TL;DR: A signature motif present in mRNAs that associate with TIA-1 is reported and provided support to the notion that Tia-1 represses the translation of target transcripts.
Journal ArticleDOI
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
Marcel P. van der Brug,Jeff Blackinton,Jeff Blackinton,Jayanth Chandran,Ling Yang Hao,Ashish Lal,Krystyna Mazan-Mamczarz,Jennifer L. Martindale,Chengsong Xie,Rili Ahmad,Kelly Jean Thomas,Alexandra Beilina,J. Raphael Gibbs,Jinhui Ding,Amanda J. Myers,Ming Zhan,Huaibin Cai,Nancy M. Bonini,Myriam Gorospe,Mark R. Cookson +19 more
TL;DR: It is shown that DJ-1 associates with RNA targets in cells and the brain, including mitochondrial genes, genes involved in glutathione metabolism, and members of the PTEN/PI3K cascade, and that Pathogenic recessive mutants are deficient in this activity.