M
Minghuang Zhang
Researcher at New York University
Publications - 16
Citations - 9768
Minghuang Zhang is an academic researcher from New York University. The author has contributed to research in topics: Tumor necrosis factor alpha & Proinflammatory cytokine. The author has an hindex of 13, co-authored 15 publications receiving 9141 citations. Previous affiliations of Minghuang Zhang include École Polytechnique Fédérale de Lausanne & North Shore University Hospital.
Papers
More filters
Journal ArticleDOI
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Lyudmila V. Borovikova,Svetlana Ivanova,Minghuang Zhang,Huan Yang,Galina I. Botchkina,Linda R. Watkins,Haichao Wang,Naji N. Abumrad,John W. Eaton,Kevin J. Tracey +9 more
TL;DR: Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock.
Journal ArticleDOI
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang,Ona Bloom,Minghuang Zhang,Jaideep M. Vishnubhakat,Michael Ombrellino,Jiantu Che,Asia Frazier,Huan Yang,Svetlana Ivanova,Lyudmila V. Borovikova,Kirk R. Manogue,Eugen Faist,Edward Abraham,Jan Andersson,Ulf Andersson,Patricia E. Molina,Naji N. Abumrad,Andrew E. Sama,Kevin J. Tracey +18 more
TL;DR: High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
Journal ArticleDOI
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.
Ulf Andersson,Haichao Wang,Karin Palmblad,Ann-Charlotte Aveberger,Ona Bloom,Helena Erlandsson-Harris,Alfred Janson,R. Kokkola,Minghuang Zhang,Huan Yang,Kevin J. Tracey +10 more
TL;DR: Results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis.
Journal ArticleDOI
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation.
Lyudmila V. Borovikova,Svetlana Ivanova,Dominic Nardi,Minghuang Zhang,Huan Yang,Michael Ombrellino,Kevin J. Tracey +6 more
TL;DR: In this paper, the role of the central nervous system (CNS) and efferent vagus nerve signaling in CNI-1493-mediated modulation of acute inflammation in the periphery was identified.
Journal ArticleDOI
Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
Haichao Wang,Jaideep M. Vishnubhakat,Ona Bloom,Minghuang Zhang,Michael Ombrellino,Andrew E. Sama,Kevin J. Tracey +6 more
TL;DR: Stimulation of pituicytes by TNF or IL-1 induces the release of HMG-1, which may participate in the regulation of neuroendocrine and immune responses to infection or injury.