M
Minglei Guo
Researcher at University of Nebraska Medical Center
Publications - 70
Citations - 2092
Minglei Guo is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Neuroinflammation & Autophagy. The author has an hindex of 24, co-authored 61 publications receiving 1598 citations. Previous affiliations of Minglei Guo include Shanghai Jiao Tong University & University of Kansas.
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Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
TL;DR: This review highlights recent advances in the field on the role of ER stress and autophagy in AD, prion diseases, PD, ALS and HAND with the involvement of key signaling pathways in these processes and implications for future development of therapeutic strategies.
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HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation
TL;DR: A novel role of Tat is demonstrated in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in microglial cells and in HIV-Tg rats administered lipopolysaccharide, which suggests NLRP3 can be envisioned as a therapeutic target for ameliorating Tat-mediated neuroinflammation.
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Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
Wei Zhang,Si Lu Yang,Mei Yang,Stephanie Herrlinger,Qiang Shao,John L. Collar,Edgar Fierro,Yanhong Shi,Aimin Liu,Hui Lu,Bruce E. Herring,Minglei Guo,Shilpa Buch,Zhen Zhao,Jian Xu,Zhipeng Lu,Jian-Fu Chen +16 more
TL;DR: It is demonstrated that WDR 62 depletion leads to neural precursor cell depletion and microcephaly via WDR62-CEP170-KIF2A pathway that promotes cilium disassembly.
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Cocaine-mediated microglial activation involves the ER stress-autophagy axis
TL;DR: It is demonstrated that cocaine exposure induced autophagy in both BV-2 and primary rat microglial cells as demonstrated by a dose- and time-dependent induction of autophile-signature proteins such as BECN1/Beclin 1, ATG5, and MAP1LC3B.
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Large-scale cDNA transfection screening for genes related to cancer development and progression
Dafang Wan,Yi Gong,Wenxin Qin,P. Zhang,Jinjun Li,Lin Wei,Xiaomei Zhou,Hongnian Li,Xiaokun Qiu,Fei Zhong,Liping He,Jian Yu,Genfu Yao,Huiqiu Jiang,Lianfang Qian,Ye Yu,Huiqun Shu,Xianlian Chen,Huili Xu,Minglei Guo,Zhimei Pan,Yan Chen,Chao Ge,Shengli Yang,Jianren Gu +24 more
TL;DR: The present assay provides a direct genomewide functional screening method that offers a better understanding of the basic machinery of oncogenesis, including previously undescribed systemic regulatory mechanisms, and also provides a tool for gene discovery with potential clinical applications.