M
Mingtong Ma
Researcher at Tongji University
Publications - 4
Citations - 89
Mingtong Ma is an academic researcher from Tongji University. The author has contributed to research in topics: Innate immune system & Proinflammatory cytokine. The author has an hindex of 2, co-authored 4 publications receiving 28 citations.
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Journal ArticleDOI
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
Haipeng Liu,Haipeng Liu,Pedro Moura-Alves,Gang Pei,Hans-Joachim Mollenkopf,Robert Hurwitz,Xiangyang Wu,Fei Wang,Siyu Liu,Mingtong Ma,Yiyan Fei,Chenggang Zhu,Anne-Britta Koehler,Dagmar Oberbeck-Mueller,Karin Hahnke,Marion Klemm,Ute Guhlich-Bornhof,Baoxue Ge,Anne Tuukkanen,Michael Kolbe,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +24 more
TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.
Journal ArticleDOI
CGAS is a micronucleophagy receptor for the clearance of micronuclei
Mengmeng Zhao,Fei Wang,Juehui Wu,Yuanna Cheng,Yajuan Cao,Xiangyang Wu,Mingtong Ma,Fen Tang,Zhi Liu,Haipeng Liu,Baoxue Ge +10 more
TL;DR: In this article, an increased frequency of micronuclei is associated with increased susceptibility to infection and increased susceptibility of the immune system to micro-microbe infection, which is a marker of genome instability and a trigger of innate immune responses.
Journal ArticleDOI
Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection.
Xiangyang Wu,Yong Wu,Ruijuan Zheng,Fen Tang,Lianhua Qin,Detian Lai,Lu Zhang,Lingming Chen,Bo Yan,Hua Yang,Yang Wang,Feifei Li,Jinyu Zhang,Fei Wang,Lin Wang,Yajuan Cao,Mingtong Ma,Zhonghua Liu,Jianxia Chen,Xiaochen Huang,Jie Wang,Ruiliang Jin,Peng Wang,Qin Sun,Wei Sha,Liang-Dong Lyu,Pedro Moura-Alves,Pedro Moura-Alves,Anca Dorhoi,Anca Dorhoi,Gang Pei,Peng Zhang,Jiayu Chen,Shaorong Gao,Felix Randow,Gucheng Zeng,Chang Chen,Xin-Shan Ye,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann,Haipeng Liu,Baoxue Ge +41 more
TL;DR: In this paper, the authors reported that mycobacterial arabinogalactan (AG) is recognized by galectin-9 and exacerbates mycobalacterial infection.
Journal ArticleDOI
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity.
Hua Yang,Fei Wang,Guo Xinya,Feng Liu,Zhonghua Liu,Xiangyang Wu,Mengmeng Zhao,Mingtong Ma,Haipeng Liu,Lianhua Qin,Lin Wang,Tianqi Tang,Wei Sha,Yang Wang,Jianxia Chen,Xiaochen Huang,Jie Wang,Cheng Peng,Ruijuan Zheng,Fen Tang,Lu Zhang,Chunyan Wu,Stefan H. Oehlers,Zhigang Song,Jialei She,Hua Feng,Xunwei Xie,Baoxue Ge +27 more
TL;DR: In this article, the authors found that mycobacteria under hypoxia markedly secrete the protein Rv0859/MMAR_4677 (Fatty acid degradation A, FadA), which is also enriched in tuberculous granulomas.