M
Mingyao Liu
Researcher at University Health Network
Publications - 951
Citations - 37247
Mingyao Liu is an academic researcher from University Health Network. The author has contributed to research in topics: Transplantation & Lung transplantation. The author has an hindex of 82, co-authored 854 publications receiving 31501 citations. Previous affiliations of Mingyao Liu include Medical Research Council & Hunan Normal University.
Papers
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Journal ArticleDOI
Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
Marcelo Cypel,Jonathan C. Yeung,Mingyao Liu,Masaki Anraku,Fengshi Chen,W. Karolak,Masaaki Sato,Jane Laratta,Sassan Azad,Mindy Madonik,Chung-Wai Chow,Cecilia Chaparro,Michael Hutcheon,Lianne G. Singer,Arthur S. Slutsky,Kazuhiro Yasufuku,Marc de Perrot,Andrew Pierre,Thomas K. Waddell,Shaf Keshavjee +19 more
TL;DR: Transplantation of high-risk donor lungs that were physiologically stable during 4 hours of ex vivo perfusion led to results similar to those obtained with conventionally selected lungs.
Journal ArticleDOI
Ischemia-reperfusion-induced lung injury.
TL;DR: Better understanding of the mechanisms of ischemia-reperfusion injury, improvements in the technique of lung preservation, and the development of a new preservation solution specifically for the lung have been associated with a reduction in the incidence of primary graft failure from approximately 30 to 15% or less.
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Injurious Mechanical Ventilation and End-Organ Epithelial Cell Apoptosis and Organ Dysfunction in an Experimental Model of Acute Respiratory Distress Syndrome
Yumiko Imai,Jean Parodo,Osamu Kajikawa,Marc de Perrot,Stefan Fischer,Vern Edwards,Ernest Cutz,Mingyao Liu,Shaf Keshavjee,Thomas R. Martin,John C. Marshall,V. Marco Ranieri,Arthur S. Slutsky +12 more
TL;DR: In this paper, the authors examined the hypothesis that an injurious ventilatory strategy may lead to end-organ epithelial cell apoptosis and organ dysfunction, and showed that a lung protection strategy led to increased rates of epithelialcell apoptosis in the kidney.
Journal ArticleDOI
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
Dali Li,Zhongwei Qiu,Yanjiao Shao,Yuting Chen,Yuting Guan,Meizhen Liu,Yongmei Li,Na Gao,Liren Wang,Xiaoling Lu,Yongxiang Zhao,Mingyao Liu,Mingyao Liu +12 more
TL;DR: A CRISPR-Cas system is used to induce genomic DNA fragment deletion in mice by coinjecting two single-guide RNAs (sgRNAs) targeting the Uhrf2 locus with Cas9 mRNA by means of a single microinjection.
Journal ArticleDOI
Technique for prolonged normothermic ex vivo lung perfusion.
Marcelo Cypel,Jonathan C. Yeung,S. Hirayama,M. Rubacha,Stefan Fischer,Masaki Anraku,Masaaki Sato,Stephen Harwood,Andrew Pierre,Thomas K. Waddell,Marc de Perrot,Mingyao Liu,Shaf Keshavjee +12 more
TL;DR: Twelve hours of EVLP at physiologic temperatures using an acellular perfusate is achievable and maintains the donor lungs without inflicting significant added injury and can be used to assess, maintain and treat injured donor lungs.