M
Mireia Castillo
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 16
Citations - 2602
Mireia Castillo is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: PTEN & Notch signaling pathway. The author has an hindex of 11, co-authored 16 publications receiving 2351 citations. Previous affiliations of Mireia Castillo include Columbia University Medical Center & Columbia University.
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Journal ArticleDOI
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero,Maria Luisa Sulis,Maria Cortina,Pedro J. Real,Kelly Barnes,Maria Ciofani,Esther Caparrós,Jean Buteau,Kristy A. Brown,Sherrie L. Perkins,Govind Bhagat,Archana M. Agarwal,Giuseppe Basso,Mireia Castillo,Satoru Nagase,Carlos Cordon-Cardo,Ramon Parsons,Juan Carlos Zúñiga-Pflücker,Maria Dominguez,Adolfo A. Ferrando +19 more
TL;DR: Findings identify transcriptional control of PTEN and regulation of the PI3K-AKT pathway as key elements of the leukemogenic program activated by NOTCH1 and provide the basis for the design of new therapeutic strategies for T-ALL.
Journal ArticleDOI
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real,Valeria Tosello,Teresa Palomero,Teresa Palomero,Mireia Castillo,Eva Hernando,Elisa de Stanchina,Maria Luisa Sulis,Maria Luisa Sulis,Kelly Barnes,Catherine M. Sawai,Irene Homminga,Jules P.P. Meijerink,Iannis Aifantis,Giuseppe Basso,Carlos Cordon-Cardo,Weiyun Z. Ai,Adolfo A. Ferrando,Adolfo A. Ferrando +18 more
TL;DR: It is shown that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo and support a role for glucocORTicoid-resistant T-ALL.
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PHF6 mutations in T-cell acute lymphoblastic leukemia
Pieter Van Vlierberghe,Pieter Van Vlierberghe,Pieter Van Vlierberghe,Teresa Palomero,Hossein Khiabanian,Joni Van der Meulen,Mireia Castillo,Nadine Van Roy,Barbara De Moerloose,Jan Philippé,Sara González-García,María L. Toribio,Tom Taghon,Linda Zuurbier,Barbara Cauwelier,Christine J. Harrison,Claire Schwab,Markus Pisecker,Sabine Strehl,Anton W. Langerak,Jozef Gecz,Edwin Sonneveld,Rob Pieters,Elisabeth Paietta,Jacob M. Rowe,Peter H. Wiernik,Yves Benoit,Jean Soulier,Bruce Poppe,Xiaopan Yao,Carlos Cordon-Cardo,Jules P.P. Meijerink,Raul Rabadan,Frank Speleman,Adolfo A. Ferrando +34 more
TL;DR: PHF6 is identified as a new X-linked tumor suppressor in T-ALL and a strong genetic interaction between PHF6 loss and aberrant expression of TLX transcription factors in the pathogenesis of this disease is pointed to.
Journal ArticleDOI
Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia
Erich Piovan,Erich Piovan,Jiyang Yu,Valeria Tosello,Daniel Herranz,Alberto Ambesi-Impiombato,Ana Carolina Da Silva,Marta Sanchez-Martin,Arianne Perez-Garcia,Isaura Rigo,Mireia Castillo,Stefano Indraccolo,Justin R. Cross,Elisa de Stanchina,Elisabeth Paietta,Elisabeth Paietta,Janis Racevskis,Janis Racevskis,Jacob M. Rowe,Martin S. Tallman,Giuseppe Basso,Jules P.P. Meijerink,Carlos Cordon-Cardo,Andrea Califano,Adolfo A. Ferrando +24 more
TL;DR: It is demonstrated that loss of PTEN and consequent AKT1 activation can effectively block glucocorticoid-induced apoptosis and induce resistance to glucoc Corticoid therapy, and pharmacologic inhibition of AKT with MK2206 effectively reverses glucocORTicoid resistance.
Journal ArticleDOI
A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis
Praveen Agrawal,Barbara Fontanals-Cirera,Elena Sokolova,Samson T. Jacob,Christopher A. Vaiana,Diana Argibay,Veronica Davalos,Meagan McDermott,Shruti Nayak,Farbod Darvishian,Mireia Castillo,Beatrix Ueberheide,Iman Osman,David Fenyö,Lara K. Mahal,Eva Hernando +15 more
TL;DR: It is demonstrated FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination.