Mireille van Westreenen

TL;DR: From diagnosis onward, distinct patterns of nasopharyngeal microbiota development in infants with CF under 6 months of age compared with control subjects are observed and a marked effect of antibiotic therapy leading toward a gram-negative microbial composition is observed.

TL;DR: The inconsistent intra-individual concordance between microbiota of the upper and lower respiratory niches suggests that the lungs of infants with CF may have their own microbiome that seems seeded by, but is not identical to, the upper respiratory tract microbiome.

TL;DR: Assessment of galactomannan in bronchoalveolar lavage fluid is a proposed tool to diagnose invasive pulmonary aspergillosis in children.

TL;DR: In this article, the authors reviewed the in vitro activities of these new antibiotics, especially against ESBL and CPE microorganisms, potential side effects, and clinical studies in complicated urinary tract infection (cUTI), intra-abdominal infections (cIAI), and hospital-acquired pneumonia/ventilator-associatedpneumonia (HAP/VAP).

TL;DR: CFD modeling showed that concentrations of inhaled antibiotic delivered to the small airways are highly patient specific and vary throughout the bronchial tree, suggesting that anti-Pa treatment of especially the smallAirway treatment of patients with CF can be improved.