M
Miriam E. van Strien
Researcher at Royal Netherlands Academy of Arts and Sciences
Publications - 19
Citations - 1048
Miriam E. van Strien is an academic researcher from Royal Netherlands Academy of Arts and Sciences. The author has contributed to research in topics: Neural stem cell & Subventricular zone. The author has an hindex of 16, co-authored 19 publications receiving 858 citations. Previous affiliations of Miriam E. van Strien include Utrecht University & Netherlands Institute for Neuroscience.
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Journal ArticleDOI
Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells
Jeroen de Vrij,S L Niek Maas,Kitty M. C. Kwappenberg,Rosalie Schnoor,Anne Kleijn,Lennard J. M. Dekker,Theo M. Luider,Lot de Witte,Manja Litjens,Miriam E. van Strien,Elly M. Hol,Jérôme Kroonen,Pierre A. Robe,Martine L.M. Lamfers,Marco W. Schilham,Marike L. D. Broekman +15 more
TL;DR: GBM‐derived EVs can modify cells of the monocytic lineage, which acquire characteristics that resemble the tumor‐supportive phenotypes observed in patients.
Journal ArticleDOI
The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain
Simone A. van den Berge,Miriam E. van Strien,Joanna A. Korecka,Anke A. Dijkstra,Jacqueline A. Sluijs,Lieneke Kooijman,Ruben Eggers,Lidia De Filippis,Angelo L. Vescovi,Joost Verhaagen,Wilma D.J. van de Berg,Elly M. Hol,Elly M. Hol +12 more
TL;DR: The adult neural stem cell pool in the subventricular zone was not clearly affected in the human parkinsonian brain or a Parkinson's disease mouse model, and it is concluded that dopamine depletion most likely has no effect on human neural stem cells.
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Expression of vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue.
Joost Smolders,Karianne G. Schuurman,Miriam E. van Strien,Jeroen Melief,Debbie A.E. Hendrickx,Elly M. Hol,Elly M. Hol,Corbert G. van Eden,Sabina Luchetti,Inge Huitinga +9 more
TL;DR: Increased VDR expression in MSNAWM and inflammatory cytokine-induced amplified expression of VDR and CYP27B1 in chronic active MS lesions suggest increased sensitivity to vitamin D in NAWM and a possible endogenous role for vitamin D metabolism in the suppression ofactive MS lesions.
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A star is born: new insights into the mechanism of astrogenesis
TL;DR: This review focuses on signaling pathways that instruct astrogenesis, incorporating recently discovered intrinsic and extrinsic regulators and highlights how key molecular pathways like JAK/STAT and Notch are integrated in a complex network of environmental signals and epigenetic and transcriptional regulators to determine NSC differentiation.
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Gender differences in multiple sclerosis: induction of estrogen signaling in male and progesterone signaling in female lesions.
Sabina Luchetti,Corbert G. van Eden,Karianne G. Schuurman,Miriam E. van Strien,Dick F. Swaab,Inge Huitinga +5 more
TL;DR: There are gender differences in the CNS of MS patients that may affect lesion pathogenesis, that is, in males, estrogen synthesis and signaling are induced; whereas in females, progestogen synthesis and signalling are induced.