Mithun Singh Rajput

Bio: Mithun Singh Rajput is an academic researcher from Devi Ahilya Vishwavidyalaya. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 12, co-authored 35 publications receiving 505 citations. Previous affiliations of Mithun Singh Rajput include Mahatma Gandhi Memorial Medical College & Shri Govindram Seksaria Institute of Technology and Science.

Physical and chemical penetration enhancers in transdermal drug delivery system

Abstract: There is considerable interest in the skin as a site of drug application for both local and systemic effect. However, the skin, in particular the stratum corneum, possesses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and to increase the range of drugs for which topical and transdermal delivery is a viable option. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, we have discussed the physical and chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

Trends in shrimp processing waste utilization: An industrial prospective

Abstract: Background Shrimp farming and processing plants are the largest seafood industry around the world due to their high demand and market value. The shrimp processing industry produces 50–60% waste of the catch volume. These wastes contain a large quantity of bioactive compounds including chitin, protein, lipid, carotenoid and minerals. Bioactive compounds from shrimp processing waste exhibit various bioactivities, and can be used as food and feed as well as ingredient in functional food preparation. The recent trend of shrimp waste utilization focuses on the bioremediation and energy conversion sectors. Scope and approach In this review, shrimp processing and the main bioactive compounds from shrimp waste were outlined. The recent applications of bioactive compounds from shrimp waste briefly describe in terms of different bioactivities, food and feed applications, and other industrial approach. Hurdles and future prospectus of shrimp processing waste utilization have been addressed. Key findings and conclusions Shrimp processing industries generate tremendous amount of waste, which can be extracted to obtain active compounds including chitin, carotenoids and protein hydrolysates, etc. These active compounds act as antioxidant, antimicrobial, anti-hypertensive, anti-inflammatory and anti-proliferative agents. Moreover, due to their functional and nutritional properties, these compounds could be used as natural safe additives or functional food/feed ingredients. Active compounds in shrimp waste open the doors of energy, solid wastes, and wastewater bioremediation. Hence, the future trends of shrimp waste utilization are the movement towards eco-friendly energy conversion, bioremediation and bioplastic area.

Microspheres in cancer therapy.

Abstract: Cancer microsphere technology is the latest trend in cancer therapy. It helps the pharmacist to formulate the product with maximum therapeutic value and minimum or negligible range side effects. Cancer is a disease in which the abnormal cells are quite similar to the normal cells, with just minute genetic or functional change. A major disadvantage of anticancer drugs is their lack of selectivity for tumor tissue alone, which causes severe side effects and results in low cure rates. Thus, it is very difficult to target abnormal cells by the conventional method of the drug delivery system. Microsphere technology is probably the only method that can be used for site-specific action, without causing significant side effects on normal cells. This review article describes various microspheres that have been prepared or formulated to exploit microsphere technology for targeted drug therapy in various cancers. We looked at the usefulness of microspheres as a tool for cancer therapy. The current review has been done using PubMed and Medline search with keywords.

Basic and Clinical Pharmacology

Abstract: This book succeeds Review of Medical Pharmacology , by Meyers, Jawetz, and Goldfien. Edited by B. G. Katzung, some of the important areas covered include drug receptors and pharmacodynamics, pharmacokinetics of absorption and biotransformation of drugs, autonomic pharmacology of cholinergic and adrenergic receptor stimulants and antagonists, antihypertensive agents, cardiac glycosides and other agents used in the treatment of congestive heart failure, therapeutic drugs for cardiac arrhythmias, diuretics, pharmacology of the CNS drugs such as anticonvulsants and anesthetics, antidepressants, narcotic analgesics, nonsteroidal anti-inflammatory agents, endocrine pharmacology, antimicrobial and antimycobacterial drugs, antiprotozoal and antihelmintic drugs, cancer chemotherapy, and drugs and the immune system. Written by several prominent researchers and scientists, each chapter begins with a section on the basic pharmacology, chemistry, pharmacokinetics, and pharmacodynamics of the agents under discussion. This is followed by a section on clinical pharmacology, which deals with relevant information regarding the clinical use of drugs on the various

Therapeutic efficacy of nanoparticles and routes of administration

Abstract: In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.