M
Mitja Mitrovic
Researcher at Yale University
Publications - 20
Citations - 6071
Mitja Mitrovic is an academic researcher from Yale University. The author has contributed to research in topics: Genome-wide association study & Linkage disequilibrium. The author has an hindex of 12, co-authored 19 publications receiving 5266 citations. Previous affiliations of Mitja Mitrovic include Broad Institute & University of Maribor.
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Journal ArticleDOI
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Luke Jostins,Stephan Ripke,Rinse K. Weersma,Richard H. Duerr,Dermot P.B. McGovern,Ken Y. Hui,James Lee,L. Philip Schumm,Yashoda Sharma,Carl A. Anderson,Jonah Essers,Mitja Mitrovic,Kaida Ning,Isabelle Cleynen,Emilie Theatre,Sarah L. Spain,Soumya Raychaudhuri,Philippe Goyette,Zhi Wei,Clara Abraham,Jean-Paul Achkar,Tariq Ahmad,Leila Amininejad,Ashwin N. Ananthakrishnan,Vibeke Andersen,Jane M. Andrews,Leonard Baidoo,Tobias Balschun,Peter A. Bampton,Alain Bitton,Gabrielle Boucher,Stephan Brand,Carsten Büning,Ariella Cohain,Sven Cichon,Mauro D'Amato,Dirk De Jong,Kathy L Devaney,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Lynnette R. Ferguson,Denis Franchimont,Karin Fransen,Richard B. Gearry,Michel Georges,Christian Gieger,Jürgen Glas,Talin Haritunians,Ailsa Hart,Christopher J. Hawkey,Matija Hedl,Xinli Hu,Tom H. Karlsen,Limas Kupčinskas,Subra Kugathasan,Anna Latiano,Debby Laukens,Ian C. Lawrance,Charlie W. Lees,Edouard Louis,Gillian Mahy,John C. Mansfield,Angharad R. Morgan,Craig Mowat,William G. Newman,Orazio Palmieri,Cyriel Y. Ponsioen,Uroš Potočnik,Natalie J. Prescott,Miguel Regueiro,Jerome I. Rotter,Richard K Russell,Jeremy D. Sanderson,Miquel Sans,Jack Satsangi,Stefan Schreiber,Lisa A. Simms,Jurgita Sventoraityte,Stephan R. Targan,Kent D. Taylor,Mark Tremelling,Hein W. Verspaget,Martine De Vos,Cisca Wijmenga,David C. Wilson,Juliane Winkelmann,Ramnik J. Xavier,Sebastian Zeissig,Bin Zhang,Clarence K. Zhang,Hongyu Zhao,Mark S. Silverberg,Vito Annese,Hakon Hakonarson,Steven R. Brant,Graham L. Radford-Smith,Christopher G. Mathew,John D. Rioux,Eric E. Schadt,Mark J. Daly,Andre Franke,Miles Parkes,Severine Vermeire,Jeffrey C. Barrett,Judy H. Cho +105 more
TL;DR: A meta-analysis of Crohn’s disease and ulcerative colitis genome-wide association scans is undertaken, followed by extensive validation of significant findings, with a combined total of more than 75,000 cases and controls.
Journal ArticleDOI
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka,Karen A. Hunt,Nicholas A. Bockett,Jihane Romanos,Vanisha Mistry,Agata Szperl,Sjoerd F. Bakker,Maria Teresa Bardella,Leena Bhaw-Rosun,Gemma Castillejo,Emilio G. de la Concha,Rodrigo Coutinho de Almeida,Kerith-Rae Dias,Cleo C. van Diemen,Patrick Dubois,Richard H. Duerr,Sarah Edkins,Lude Franke,Karin Fransen,Javier Gutierrez,Graham A. Heap,Barbara Hrdličková,Sarah E. Hunt,Leticia Plaza Izurieta,V. Izzo,Leo A. B. Joosten,Cordelia Langford,Maria Cristina Mazzilli,Charles A. Mein,Vandana Midah,Mitja Mitrovic,Barbara Mora,Marinita Morelli,Sarah Nutland,Concepción Núñez,Suna Onengut-Gumuscu,Kerra Pearce,Mathieu Platteel,Isabel Polanco,Simon C. Potter,Carmen Ribes-Koninckx,Isis Ricaño-Ponce,Stephen S. Rich,Anna Rybak,Jose Luis Santiago,Sabyasachi Senapati,Ajit Sood,Hania Szajewska,Riccardo Troncone,Jezabel Varadé,Chris Wallace,Victorien M. Wolters,Alexandra Zhernakova,B.K. Thelma,Bożena Cukrowska,Elena Urcelay,Jose Ramon Bilbao,M. Luisa Mearin,Donatella Barisani,Jeffrey C. Barrett,Vincent Plagnol,Panos Deloukas,Cisca Wijmenga,David A. van Heel +63 more
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Journal ArticleDOI
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismüller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Müller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Nöthen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. König,Kristian Hveem,Isabelle Cleynen,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Björnsson,Richard Sandford,Peter R. Durie,Espen Melum,Espen Melum,Morten H. Vatn,Morten H. Vatn,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Jean-Paul Achkar,Kirsten Muri Boberg,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +95 more
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Jimmy Z. Liu,Johannes R. Hov,Trine Folseraas,Eva Ellinghaus,Simon M. Rushbrook,Nadezhda Tsankova Doncheva,Ole A. Andreassen,Rinse K. Weersma,Tobias J. Weismueller,Bertus Eksteen,Pietro Invernizzi,Gideon M. Hirschfield,Daniel Gotthardt,Albert Parés,David Ellinghaus,Tejas Shah,Brian D. Juran,Piotr Milkiewicz,Christian Rust,Christoph Schramm,Tobias Mueller,Brijesh Srivastava,Georgios N. Dalekos,Markus M. Noethen,Stefan Herms,Juliane Winkelmann,Mitja Mitrovic,Felix Braun,Cyriel Y. Ponsioen,Peter J. P. Croucher,Martina Sterneck,Andreas Teufel,Andrew Mason,Janna Saarela,Virpi Leppa,Ruslan Dorfman,Domenico Alvaro,Annarosa Floreani,Suna Onengut-Gumuscu,Stephen S. Rich,Wesley K. Thompson,Andrew J. Schork,Sigrid Næss,Ingo Thomsen,Gabriele Mayr,Inke R. Koenig,Kristian Hveem,Isabelle Cleynen,Javier Gutierrez-Achury,Isis Ricaño-Ponce,David A. van Heel,Einar Bjoernsson,Richard Sandford,Peter R. Durie,Espen Melum,Morten H. Vatn,Mark S. Silverberg,Richard H. Duerr,Leonid Padyukov,Stephan Brand,Miquel Sans,Vito Annese,Jean-Paul Achkar,Kirsten Muri Boberg,Hanns-Ulrich Marschall,Olivier Chazouillères,Christopher L. Bowlus,Cisca Wijmenga,Erik Schrumpf,Severine Vermeire,Mario Albrecht,John D. Rioux,Graeme J.M. Alexander,Annika Bergquist,Judy H. Cho,Stefan Schreiber,Michael P. Manns,Martti Färkkilä,Anders M. Dale,Roger W. Chapman,Konstantinos N. Lazaridis,Andre Franke,Carl A. Anderson,Tom H. Karlsen +83 more
Abstract: Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
Journal ArticleDOI
Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity
Prithvi Raj,Ekta Rai,Ekta Rai,Ran Song,Shaheen Khan,Benjamin E. Wakeland,Kasthuribai Viswanathan,Carlos Arana,Chaoying Liang,Bo Zhang,Igor Dozmorov,Ferdicia Carr-Johnson,Mitja Mitrovic,Graham B. Wiley,Jennifer A. Kelly,Bernard Lauwerys,Nancy J. Olsen,Chris Cotsapas,Christine Kim Garcia,Carol Wise,John B. Harley,John B. Harley,Swapan K. Nath,Judith A. James,Chaim O. Jacob,Betty P. Tsao,Chandrashekhar Pasare,David R. Karp,Quan Zhen Li,Patrick M. Gaffney,Edward K. Wakeland +30 more
TL;DR: Targeted sequencing of sixteen SLE risk loci among 1349 Caucasian cases and controls produced a comprehensive dataset of the variations causing susceptibility to systemic lupus erythematosus, demonstrating that common disease alleles contain multiple causal variants modulating multiple immune system genes.