M
Mitsuhiko Ikura
Researcher at Princess Margaret Cancer Centre
Publications - 322
Citations - 36071
Mitsuhiko Ikura is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Calmodulin & Endoplasmic reticulum. The author has an hindex of 89, co-authored 316 publications receiving 34132 citations. Previous affiliations of Mitsuhiko Ikura include Structural Genomics Consortium & National Institutes of Health.
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Journal ArticleDOI
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
Atsushi Miyawaki,Juan Llopis,Roger Heim,J. Michael McCaffery,Joseph A. Adams,Mitsuhiko Ikura,Mitsuhiko Ikura,Roger Y. Tsien +7 more
TL;DR: New fluorescent indicators for Ca2+ that are genetically encoded without cofactors and are targetable to specific intracellular locations are constructed and dubbed ‘cameleons’.
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Rapid recording of 2D NMR spectra without phase cycling. Application to the study of hydrogen exchange in proteins
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Solution structure of a calmodulin-target peptide complex by multidimensional NMR.
TL;DR: In this article, the three-dimensional solution structure of the complex between calcium-bound calmodulin (Ca(2+)-CaM) and a 26-residue synthetic peptide comprising the CaM binding domain (residues 577 to 602) of skeletal muscle myosin light chain kinase, has been determined using multidimensional heteronuclear filtered and separated nuclear magnetic resonance spectroscopy.
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Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.
TL;DR: The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements, showing a high degree of mobility near the middle of the central helix and anisotropy observed in the motion of the two globular cal modulin domains is much smaller than expected.