M
Miyuki Yano
Researcher at Kumamoto University
Publications - 11
Citations - 1310
Miyuki Yano is an academic researcher from Kumamoto University. The author has contributed to research in topics: Macrophage proliferation & MAPK/ERK pathway. The author has an hindex of 10, co-authored 11 publications receiving 1247 citations. Previous affiliations of Miyuki Yano include University of Tokyo.
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Journal ArticleDOI
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Daisuke Kukidome,Takeshi Nishikawa,Kazuhiro Sonoda,Koujiro Imoto,Kazuo Fujisawa,Miyuki Yano,Hiroyuki Motoshima,Tetsuya Taguchi,Takeshi Matsumura,Eiichi Araki +9 more
TL;DR: Results suggest that metformin normalizes hyperglycemia-induced mtROS production by induction of MnSOD and promotion of mitochondrial biogenesis through the activation of AMPK-PGC-1alpha pathway.
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Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression
Motoyuki Igata,Hiroyuki Motoshima,Kaku Tsuruzoe,Kanou Kojima,Takeshi Matsumura,Tatsuya Kondo,Tetsuya Taguchi,Kazuhiko Nakamaru,Miyuki Yano,Daisuke Kukidome,K. Matsumoto,Tetsushi Toyonaga,Tomoichiro Asano,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: The data suggest for the first time that AMPK suppresses VSMC proliferation via cell cycle regulation by p53 upregulation and AMPK activation in VSMCs may be a therapoietic target for the prevention of vascular diseases.
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Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependent Cyclooxygenase-2 Expression in Macrophages
Miyuki Yano,Takeshi Matsumura,Takafumi Senokuchi,Norio Ishii,Yusuke Murata,Kayo Taketa,Hiroyuki Motoshima,Tetsuya Taguchi,Kazuhiro Sonoda,Daisuke Kukidome,Yoh Takuwa,Teruo Kawada,Michael Brownlee,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: It is demonstrated that statins inhibited lipopolysaccharide-induced tumor necrosis factor α or monocyte chemoattractant protein-1 mRNA expression, and these effects by statins were abrogated by the PPARγ antagonist T0070907 or by small interfering RNA of PPARβ or PPARα.
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Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling.
Koujiro Imoto,Daisuke Kukidome,Takeshi Nishikawa,Takako Matsuhisa,Kazuhiro Sonoda,Kazuo Fujisawa,Miyuki Yano,Hiroyuki Motoshima,Tetsuya Taguchi,Kaku Tsuruzoe,Takeshi Matsumura,Hidenori Ichijo,Eiichi Araki +12 more
TL;DR: The results suggest that TNF-α increases mitochondrial ROS and activates ASK1 in Huh7 cells and that these T NF-α–induced phenomena contribute, at least in part, to impaired insulin signaling.
Journal ArticleDOI
Statins Suppress Oxidized Low Density Lipoprotein-induced Macrophage Proliferation by Inactivation of the Small G Protein-p38 MAPK Pathway
Takafumi Senokuchi,Takeshi Matsumura,Masakazu Sakai,Miyuki Yano,Tetsuya Taguchi,Tomoko Matsuo,Kazuhiro Sonoda,Daisuke Kukidome,Koujiroh Imoto,Takeshi Nishikawa,Shokei Kim-Mitsuyama,Yoh Takuwa,Eiichi Araki +12 more
TL;DR: In conclusion, statins inhibited GM-CSF-induced Ras- or RhoA-p38 MAPK signal cascades, thereby suppressing Ox-LDL-induced macrophage proliferation.