Moammir H. Aziz

TL;DR: It is believed that continued efforts are needed, especially well-designed pre-clinical studies in the animal models that closely mimic/represent human disease, to establish the usefulness of resveratrol as cancer chemopreventive agent.

TL;DR: It is demonstrated that 1) resveratrol imparts strong chemopreventive effects against UVB exposure‐mediated skin carcinogenesis (relevant to human skin cancers), and 2) theChemoprevention of UVB‐mediatedskin carcinogenesis by resver atrol may, at least in part, be mediated via modulations in Survivin and other associated events.

TL;DR: It is suggested that resveratrol could be developed as an agent for the management of prostate cancer because of its inhibition of phosphatidylinositol 3′-kinase/Akt activation that results in modulations in Bcl-2 family proteins in such a way that the apoptosis of LNCaP cells is promoted.

TL;DR: Plumbagin inhibits multiple molecular targets including PKCepsilon, a predictive biomarker of PCa aggressiveness and may be a novel agent for therapy of hormone-refractory PCa.

TL;DR: Sanguinarine induced growth inhibitory and antiproliferative effects in human prostate carcinoma cells irrespective of their androgen status and results suggest that sanguinine may be developed as an agent for the management of prostate cancer.