Mohamed Lamkanfi

TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.

TL;DR: This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field.

TL;DR: The recent understanding in NLRs is discussed, which indicates that two NLRs sense the cytosolic presence of the peptidoglycan fragments meso-DAP and muramyl dipeptide, respectively, and drive the activation of mitogen-activated protein kinase and the transcription factor NF-kappaB.

TL;DR: It is shown that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis and defective inflammasome activation led to loss of epithelial integrity, resulting in systemic dispersion of commensal bacteria, massive leukocyte infiltration and increased chemokine production in the colon.

TL;DR: This review presents recently gained insight on the distinct inflammasome types, their activation and effector mechanisms, and their modulation by microbial virulence factors and discusses recently gained knowledge on the role of deregulated inflammal activity in human autoinflammatory, autoimmune, and infectious diseases.