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Mohammad Ali Ebrahimzadeh

Bio: Mohammad Ali Ebrahimzadeh is an academic researcher from Mazandaran University of Medical Sciences. The author has contributed to research in topics: DPPH & Gallic acid. The author has an hindex of 36, co-authored 244 publications receiving 5630 citations. Previous affiliations of Mohammad Ali Ebrahimzadeh include University of Tehran & Shahid Beheshti University of Medical Sciences and Health Services.


Papers
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Journal Article
TL;DR: Methanolic extracts of 13 commercially available citrus spp.
Abstract: Methanolic extracts of 13 commercially available citrus spp., peels and tissues growing in Iran were investigated for their antioxidant activity by DPPH method. IC50 for antioxidant activity ranged from 0.6-3.8 mg ml(-1). Total phenolic content of the citrus spp. samples (based on folin Ciocalteu method) varied from 66.5 to 396.8 mg gallic acid equivalent/g of extract and flavonoids content (based on colorimetric AlCl3 method) varied from 0.3 to 31.1 mg quercetin equivalent/g of extract. There were no correlation between the total phenolic and/or flavonoids contents and antioxidant activity in tissues and/or peels.

519 citations

Journal ArticleDOI
TL;DR: The antioxidant activity of the aerial parts of Ferula assafoetida was determined by employing various in vitro assay systems as discussed by the authors, and the extracts showed good nitric oxide-scavenging activity (IC 50 was 270 ± 3) and Fe 2+ chelating ability, IC 50 was 0.57 ± 0.02 mg ml -1 ).
Abstract: The antioxidant activity of the aerial parts of Ferula assafoetida was determined by employing various in vitro assay systems. IC 50 for DPPH radical-scavenging activity was 380 ± 12 mg ml -1 . The extracts showed good nitric oxide-scavenging activity (IC 50 was 270 ± 3) and Fe 2+ chelating ability (IC 50 was 0.57 ± 0.02 mg ml -1 ). The peroxidation inhibition (antioxidant activity) of the extracts exhibited values from 82% (at 24 hrs) and 88% (at 72 hrs). The extract exhibited a fairy weak reducing power at 25-800 μg ml -1 of extracts which was not comparable with Vitamin C (p 3 method) was 90.9 ± 6.3 mg quercetin equivalent/g of extract powder.

360 citations

Journal ArticleDOI
TL;DR: In this article, the authors determined the iron chelating activity of some medicinal plants and determined to find alternative sources with lower side effects in thalassemic patients by soaking dry material of the selected plant in appropriate solvent.
Abstract: Thalassemia major is characterized by anemia, iron overload, further potentiation of reactive oxygen species (ROS) and damage to major organs, especially the cardiovascular system. Antioxidant and other supportive therapies protect red blood cells (RBC) against antioxidant damage. Chelation therapy reduces iron-related complications and thereby improves quality of life and overall survival. The poor oral bioavailability, short plasma half-life and severe side effects of available chelators are still not optimal. In this study, iron chelating activity of some medicinal plants was determined to find alternative sources with lower side effects in thalassemic patients. Extracts were prepared by soaking dry material of the selected plant in appropriate solvent. Phenol and flavonoid content of the extract were measured by folin ciocalteu and AlCl3 assays. Phenol content of the extracts varied between 9 -290 mg/g. The largest amount of phenolic compounds and highest chelating activity were found in Mellilotus arvensis. All extracts contained various amount of flavonoids from 10 to 60 mg/g. Extracts with high phytochemicals and chelating activity can be observed as a good source of new agents for thalassemic patients.

336 citations

Journal Article
TL;DR: In this paper, the antioxidant properties of ethanol-water extract from corn silk were estimated by different methods, including phenol and flavonoid content measured by Folin Ciocalteu and AlCl3 assays.
Abstract: Traditionally corn silk (CS) has been used as diuretic, antilithiasic, uricosuric, and antiseptic. It is used for the treatment of edema as well as for cystitis, gout, kidney stones, nephritis, and prostatitis. In the present study, the antioxidant properties of ethanol-water extract from CS were estimated by different methods. Also phenol and flavonoid content of the extract were measured by Folin Ciocalteu and AlCl3 assays. CS extract contained a significant amount of phenol and flavonoids. The percentage of DPPH radical scavenged by CS extract was 92.6 at a concentration of 1.6 mg ml-1. IC50 of the extract and the standard compounds butylated hydroxytoluene (BHA) and quercetin was 0.59, 0.053, and 0.025 mg ml-1, respectively. Iron chelating activity of the extract was less than the standard compounds. CS extract showed nitric oxide-scavenging effect less than the reference agent (quercetin). The extract showed a high reducing ability. According to ferric thiocyanate (FTC) method, the extract showed more than 88% inhibition of linoleic acid peroxidation. It might be concluded that some of the properties of CS in traditional medicine is due to its antioxidant ability.

291 citations

Journal Article
TL;DR: The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts, which exhibited very low and moderate concentration-dependent antioxidant activity in FTC methods.
Abstract: Extracts of 4 medicinal and aromatic plants were investigated for their antioxidant potency employing six various established in vitro system: H. officinalis L. var. angustifolius aerial parts, C. speciosum flowers, V. odorata and B. hyrcana leaves.With regard to IC50 values (microg/ml), the order in DPPH radical-scavenging were CS (585.6) > HO (311) > VO (245.1) > and BH (113.1). Effectiveness in reducing powers were high and in a descending order of HO > CS > BH > VO (at the concentrations of 25-800 microg/ml). IC50 for Fe2+ chelating ability were 188, 750 and 980 microg/ml for VO, CS and HO, respectively. BH extract has shown only 38% inhibition at 800 microg/ml. The extracts showed weak nitric oxide-scavenging activity. All extracts exhibited very low and moderate concentration-dependent antioxidant activity in FTC methods. IC50 for scavenging of H2O2 were 169 for BH, 175 for CS, 640 for VO and 663 microg/ml for HO. The content of total phenolic compounds and flavonoids were measured in plant extracts. The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts.

218 citations


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01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

Journal ArticleDOI
Nicolas Vabret1, Graham J. Britton1, Conor Gruber1, Samarth Hegde1, Joel Kim1, Maria Kuksin1, Rachel Levantovsky1, Louise Malle1, Alvaro Moreira1, Matthew D. Park1, Luisanna Pia1, Emma Risson1, Miriam Saffern1, Bérengère Salomé1, Myvizhi Esai Selvan1, Matthew P. Spindler1, Jessica Tan1, Verena van der Heide1, Jill Gregory1, Konstantina Alexandropoulos1, Nina Bhardwaj1, Brian D. Brown1, Benjamin Greenbaum1, Zeynep H. Gümüş1, Dirk Homann1, Amir Horowitz1, Alice O. Kamphorst1, Maria A. Curotto de Lafaille1, Saurabh Mehandru1, Miriam Merad1, Robert M. Samstein1, Manasi Agrawal, Mark Aleynick, Meriem Belabed, Matthew Brown1, Maria Casanova-Acebes, Jovani Catalan, Monica Centa, Andrew Charap, Andrew K Chan, Steven T. Chen, Jonathan Chung, Cansu Cimen Bozkus, Evan Cody, Francesca Cossarini, Erica Dalla, Nicolas F. Fernandez, John A. Grout, Dan Fu Ruan, Pauline Hamon, Etienne Humblin, Divya Jha, Julia Kodysh, Andrew Leader, Matthew Lin, Katherine E. Lindblad, Daniel Lozano-Ojalvo, Gabrielle Lubitz, Assaf Magen, Zafar Mahmood2, Gustavo Martinez-Delgado, Jaime Mateus-Tique, Elliot Meritt, Chang Moon1, Justine Noel, Timothy O'Donnell, Miyo Ota, Tamar Plitt, Venu Pothula, Jamie Redes, Ivan Reyes Torres, Mark P. Roberto, Alfonso R. Sanchez-Paulete, Joan Shang, Alessandra Soares Schanoski, Maria Suprun, Michelle Tran, Natalie Vaninov, C. Matthias Wilk, Julio A. Aguirre-Ghiso, Dusan Bogunovic1, Judy H. Cho, Jeremiah J. Faith, Emilie K. Grasset, Peter S. Heeger, Ephraim Kenigsberg, Florian Krammer1, Uri Laserson1 
16 Jun 2020-Immunity
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.

1,350 citations

Journal Article
TL;DR: This is a paid internship where interns work directly to assist the Director of Marketing and Communications on various tasks relating to upcoming GRA events.
Abstract: OVERVIEW The GRA Marketing Internship Program is offered to students who are interested in gaining valuable work experience through efforts in marketing, membership, sales, and events. Interns work directly to assist the Director of Marketing and Communications on various tasks relating to upcoming GRA events. During this internship, students will work a minimum of 10 hours a week and a maximum of 20 hours a week. Students are encouraged to earn credit for their internship, however this is a paid internship. Students interested in obtaining credit for their internship must consult their academic advisor or the intern coordinator at their academic unit.

1,309 citations

01 Jan 2007
TL;DR: The terms "antioxidant", "oxidative stress" and "oxoidative damage" are widely used but rarely defined as discussed by the authors, and a brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.
Abstract: The terms 'antioxidant', 'oxidative stress' and 'oxidative damage' are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.

1,309 citations