Author
Mohammad Reza Sharifi
Bio: Mohammad Reza Sharifi is an academic researcher from Isfahan University of Medical Sciences. The author has contributed to research in topics: Dentate gyrus & Hippocampus. The author has an hindex of 16, co-authored 29 publications receiving 574 citations.
Topics: Dentate gyrus, Hippocampus, Chronic stress, microRNA, Propidium iodide
Papers
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TL;DR: As exercise can activate many neurotransmitter systems involved in the addiction process and increase the release of endorphins, it is likely that the effect of short-term and mid-term exercises on the self-administration of morphine in rats will decrease.
75 citations
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TL;DR: The present results suggest that spatial learning and memory is affected under diabetic conditions and that treadmill running prevents these effects, and correspond to the possibility that treadmillRunning is helpful in the prevention and alleviation of the cognitive decline in diabetes mellitus.
59 citations
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TL;DR: It can be concluded that a potential time-dependent involvement of stress and recovery period on the level of BDNF might promote adaptive effects on memory and CORT level.
51 citations
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TL;DR: GA whose beneficial effect was comparable to that of insulin, also increased glucose infusion rate during an euglycemic clamp, and GABA could improve insulin resistance via rising GLUT4 and also decreasing the gluconeogenesis pathway and Glucagon receptor gene expression.
49 citations
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TL;DR: In this paper, the authors performed inhibition of miR-92a in an acute promyelocytic leukemia (APL) cell line (HL-60) using locked nucleic acid (LNA) antagomir.
Abstract: MicroRNAs (miRNAs) are endogenous non-coding RNAs, 19–25 nucleotides in length involved in post-transcriptional regulation of gene expression of great majority of the human protein coding genes. Different aspects of cellular activities like cell growth, proliferation, and differentiation are regulated by miRNAs through their interaction with particular RNA species. In many tumors up or down-regulation of different miRNAs has been reported. Human miR-17-92 gene cluster is located on 13q31.3, rooming several miRNAs including miR-17-5p, miR-17-3p, miR-18, miR-19a, miR-20a and miR-92a. Amplification or overexpression of this cluster has been reported in acute myeloid leukemia, acute lymphoblastic leukemia and several other cancer types. Here, we performed inhibition of miR-92a in an acute promyelocytic leukemia (APL) cell line (HL-60) using locked nucleic acid (LNA) antagomir. In different time points after LNA-anti-miR92a transfection, MTT assay and annexin/propidium iodide staining were performed. These assessments indicate that miR-92a inhibition can extensively decrease the viability of these cells which is mainly due to induction of apoptosis. Western blot analysis of p63 protein also revealed that miR-92a inhibition resulted in p63 expression, hence activation of cellular pathways which are normally controlled by p63 protein are retrieved. These findings could open up a path to the miRNAs based therapeutic approach for treatment of APL.
42 citations
Cited by
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TL;DR: Experimental PsychologyIts Scope and Method is illustrated by Jean-François Le Ny, G. Oléron and César Florés.
Abstract: Experimental Psychology Its Scope and Method. IV. Learning and Memory. By Jean-Francois Le Ny, G. De Montpellier, G. Oleron and Cesar Flores. Translated by Louise Elkington. Edited by P. Fraisse and Jean Piaget. Pp. viii + 376. (Routledge and Kegan Paul: London, April 1970.) 80s.
991 citations
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TL;DR: Results suggest an anti-depressant effect of L. helveticus NS8 in rats subjected to chronic restraint stress depression and that this effect could be due to the microbiota-gut-brain axis and suggest the therapeutic potential of LactobacillusNS8 in stress-related and possibly other kinds of depression.
465 citations
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348 citations
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TL;DR: Exposure to non-drug rewards can alter neural plasticity in regions of the brain that are affected by drugs of abuse, and repeated exposure to natural rewards might induce neuroplasticity that either promotes or counteracts addictive behavior.
286 citations
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TL;DR: Clinical and preclinical evidence for the efficacy of exercise at different phases of the addiction process and potential neurobiological mechanisms are discussed focusing on interactions with dopaminergic and glutamatergic signaling and chromatin remodeling in the reward pathway.
239 citations