Mohammad Reza Zali

Bio: Mohammad Reza Zali is an academic researcher from Shahid Beheshti University of Medical Sciences and Health Services. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 51, co-authored 804 publications receiving 12541 citations. Previous affiliations of Mohammad Reza Zali include Tabriz University of Medical Sciences & Universidad de Ciencias Medicas.

FBXW7/hCDC4 is a general tumor suppressor in human cancer

Abstract: The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, wh ...

Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial.

Abstract: BackgroundEnd-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment.MethodsEight patients (four hepatitis B, one hepatitis C, one alcoholic, and two crypt

Hepatitis c virus in iran: epidemiology of an emerging infection

Abstract: Hepatitis C infection has come to the top of virus-induced liver diseases in many parts of the world. In Iran, it seems that its prevalence in general population is less than 1%, which is much lower than in most of the regional countries. However, the infection is emerging mostly due to problem of intravenous drug abuse and needle-sharing in the country. On the other hand, an increase in number of centers providing hemodialysis and transfusion facilities for hemoglobinopathies generated new sources and susceptible populations in Iran. This article aims to summarize available data of Iran and to compare them with those of similar countries to find better preventive means.

Inflammatory bowel disease in Iran: a review of 457 cases.

Abstract: Background and Aims: Inflammatory bowel disease (IBD) was believed to be infrequent in Iran; however, unofficial reports have confessed the continuing rise in IBD in our country. Methods: Demographic and clinical features, extraintestinal manifestations, extension of disease and complications of 401 patients with ulcerative colitis (UC), 47 with Crohn's disease (CD), and nine with indeterminatn colitis (IC) were assessed retrospectively. The exact course of physicians’ visits of 250 IBD patient was asked through face-to-face interview. Results: Mean age at diagnosis was 31.9 years in UC and 30.5 years in CD patients. The male to female ratio was 0.8 for UC and 1.3 for CD. The percentage of CD and UC patients who were non-smokers was 82.9 and 84.5%, respectively. Patients with UC presented with rectal bleeding (41.9%), whereas those with CD complained of abdominal pain (46.9%). Among UC patients, proctosigmoid was affected in 51.9%. Colorectal cancer was diagnosed in two patients. The mean lag time between the onset of symptoms and definite diagnosis was 13.9 and 17.7 months for UC and CD patients, respectively. A total of 32.4% of patients with IBD had at least one of the five major extra-intestinal diseases. Conclusion: The demographic and clinical picture of IBD is more or less the same as that of other developing countries; however, the rarity of CD in Iran is noted. Although the true epidemiologic profile of IBD in Iran is still unknown, it is not as rare as previously thought, and it seems as if gradual adoption of a Western lifestyle may be associated with the continuing rise in IBD. © 2005 Blackwell Publishing Asia Pty Ltd