Author
Mohammad Shahidul Islam
Other affiliations: Banasthali Vidyapith
Bio: Mohammad Shahidul Islam is an academic researcher from King Saud University. The author has contributed to research in topics: Indole test & Isatin. The author has an hindex of 15, co-authored 64 publications receiving 623 citations. Previous affiliations of Mohammad Shahidul Islam include Banasthali Vidyapith.
Papers
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TL;DR: Compound 4k proved to retain a high cytotoxic activity and selectivity against colon cancer cells HCT-116, hepatocellular carcinoma, and prostate cancer cells PC-3 in comparison to cisplatin, and ligand Efficiency and Ligand Lipophilic Efficiency were evaluated and revealed that compound 4k had acceptable value.
59 citations
TL;DR: A one-pot three-component reaction via a [3 + 2] cycloaddition/ring contraction sequence of a dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without the use of any catalyst provides efficient access to synthetically useful and biologically important spirooxindoles in high yield with high diastereoselectivity.
Abstract: Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate a one-pot three-component reaction via a [3 + 2] cycloaddition/ring contraction sequence of a dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without the use of any catalyst. The reaction provides efficient access to synthetically useful and biologically important spirooxindoles in high yield (69–94%) with high diastereoselectivity. The synthesized compounds were subjected to cytotoxicity evaluation using colorectal cancer (HCT-116), hepatocellular carcinoma (HepG2), and prostate cancer (PC-3) cells. Compounds 4i, 4j, and 4k showed potent cytotoxic activity and high selectivity against HCT-116 cells when compared to cisplatin. Meanwhile compound 4d retained high cytotoxic activity and selectivity against HepG2 and PC-3 cells in comparison to cisplatin. The mechanism of compound 4d was further studied using phosphodiesterase 1 enzyme and showed 74.2% inhibitory activity. A possible binding mode for compound 4d to PDE-1 was investigated by molecular modeling using OpenEye software. Pose predictions for the active compounds were demonstrated by ROCS alignments. Compound 4d has a special geometry and differs from other active compounds.
50 citations
TL;DR: A series of chiral ligands with an imidazoline-oxazoline framework have been developed as new type of non-symmetric N,N-bidentate ligands as discussed by the authors.
45 citations
TL;DR: A facile protocol, efficient, and environmentally benign for the synthesis a series of barbiturate acid substituted at C5 position 3a-o and in sillico investigation was carried out to investigate bonding mode of barbenurate acid derivatives.
41 citations
TL;DR: The mechanism underlying the anticancer activity of compound 4d inhibited colony formation, cell migration, arrested cancer cell growth at G2/M, and induced apoptosis through intrinsic and extrinsic pathways.
41 citations
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Book•
01 Jan 1997
TL;DR: The comprehensive Heterocyclic Chemistry was published in 1984 and is now available on CD-ROM as discussed by the authors. But it is not available on the Internet yet, as it was not available before 1984.
Abstract: "Comprehensive Heterocyclic Chemistry" was published in 1984 and is now available on CD-ROM.
332 citations
TL;DR: The present review article offers a detailed account of the design strategies employed for the synthesis of nitrogen-containing anticancer agents and a systematic analysis of the structure-activity relationship among the series.
301 citations
TL;DR: The everincreasing interest in the Suzuki-Miyaura cross-coupling reaction (SMR) and its applications has increased exponentially in the last decade, which speaks volumes about its efficiency and effectiveness as mentioned in this paper.
280 citations
257 citations