M
Mohammed A. A. El-Nassag
Researcher at Al-Azhar University
Publications - 11
Citations - 155
Mohammed A. A. El-Nassag is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Chemistry & Cell cycle checkpoint. The author has an hindex of 6, co-authored 9 publications receiving 84 citations. Previous affiliations of Mohammed A. A. El-Nassag include Jazan University.
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Journal ArticleDOI
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.
Fawzia F. Al-blewi,Rawda M. Okasha,Zainab M. Hritani,Hany M. Mohamed,Hany M. Mohamed,Mohammed A. A. El-Nassag,Mohammed A. A. El-Nassag,Ahmed Halawa,Ahmed Mora,Ahmed M. Fouda,Mohammed A. Assiri,Al-Anood M. Al-Dies,Tarek H. Afifi,Ahmed M. El-Agrody +13 more
TL;DR: It is found that these three potent cytotoxic compounds induce cell cycle arrest at the S and G2/M phases, which causes apoptosis, and significantly inhibit the invasion and migration of the different tested cancer cells.
Journal ArticleDOI
Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.
Hany E.A. Ahmed,Mohammed A. A. El-Nassag,Ahmed H. Hassan,Rawda M. Okasha,Saleh Ihmaid,Ahmed M. Fouda,Tarek H. Afifi,Ateyatallah Aljuhani,Ahmed M. El-Agrody +8 more
TL;DR: The apoptotic mechanistic pathway of the cytotoxicity of the target compounds is explored and it is revealed that most of these compounds enhance the Caspase 3/7 activity that could be considered as potential anticancer agents.
Journal ArticleDOI
Synthesis and Biological Screening of 4-Benzyl-2H-phthalazine Derivatives
Ashraf H. F. Abd El-Wahab,Hany M. Mohamed,Ahmed M. El-Agrody,Mohammed A. A. El-Nassag,Ahmed H. Bedair +4 more
TL;DR: In this paper, 4-benzyl-2-substituted phthalazin-1-one derivatives were reported and their structures were confirmed by their elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral studies.
Journal ArticleDOI
Developing lipophilic aromatic halogenated fused systems with specific ring orientations, leading to potent anticancer analogs and targeting the c-Src Kinase enzyme
Hany E.A. Ahmed,Hany E.A. Ahmed,Mohammed A. A. El-Nassag,Mohammed A. A. El-Nassag,Ahmed H. Hassan,Ahmed H. Hassan,Hany M. Mohamed,Hany M. Mohamed,Ahmed Halawa,Rawda M. Okasha,Saleh Ihmaid,Shimaa M. Abd El-Gilil,Essam Shawky A. E. H. Khattab,Ahmed M. Fouda,Ahmed M. El-Agrody,Ateyatallah Aljuhani,Tarek H. Afifi +16 more
TL;DR: The combined microwave assisted synthesis, spectroscopic analyses, cytotoxic effects, and molecular docking studies of the chromene fused ring systems with various substituents of the terminal halogenated phenyl ring derivatives of 6-methoxy-4H-benzo [h]chromene (4a-m) showed a promising interaction with the c-Src Kinase, which leads to a strong inhibition of this enzyme.
Journal ArticleDOI
Synthesis and antimicrobial activity of thioxopyrimidines and related derivatives
Ahmed M. El-Agrody,Fawzy M. Ali,Fathy A. Eid,Mohammed A. A. El-Nassag,Gamal El-Sherbeny,Ahmed H. Bedair +5 more
TL;DR: In this article, the interaction of thiourea with activated cyanoolefins under different reaction conditions was studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, and 21) and related derivatives (10, 11, 14, 16, and 17) were obtained respectively.