M
Mohammed Naeem Khan
Researcher at Ulster University
Publications - 8
Citations - 224
Mohammed Naeem Khan is an academic researcher from Ulster University. The author has contributed to research in topics: Piceatannol & Cancer. The author has an hindex of 5, co-authored 8 publications receiving 134 citations.
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Journal ArticleDOI
Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α.
Alaa A. A. Aljabali,Hamid A. Bakshi,Faruck Lukmanul Hakkim,Yusuf A. Haggag,Khalid M. Al-Batanyeh,Mazhar Salim Al Zoubi,Bahaa Al-Trad,Mohamed M. Nasef,Saurabh Satija,Meenu Mehta,Kavita Pabreja,Vijay Mishra,Mohammed Naeem Khan,Salem Abobaker,Ibrahim M. Azzouz,Harish Dureja,Ritesh M. Pabari,Ashref Ali K. Dardouri,Prashant Kesharwani,Gaurav Gupta,Shakti D. Shukla,Parteek Prasher,Nitin Charbe,Poonam Negi,Deepak N. Kapoor,Dinesh Kumar Chellappan,Mateus Webba da Silva,Paul Thompson,Kamal Dua,Paul A. McCarron,Murtaza M. Tambuwala +30 more
TL;DR: The overall results indicate that PIC, when formulated as PIC–BSA NPs, enhances its therapeutic potential and could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails.
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Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A).
TL;DR: It is indicated that curcumin can effectively lower the elevated levels of HIF-1α and nuclear p65 in breast and lung cancer cells under an hypoxic tumour micro-environment when delivered in nanoparticulate form.
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Caffeic acid phenethyl ester is protective in experimental ulcerative colitis via reduction in levels of pro-inflammatory mediators and enhancement of epithelial barrier function
TL;DR: The results show that CAPE is effective in suppressing inflammation-triggered MPO activity and pro-inflammatory cytokines production while enhancing epithelial barrier function in experimental colitis, and could be a potential therapeutic agent for further clinical investigations for treatment of inflammatory bowel diseases in humans.
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Albumin nano-encapsulation of caffeic acid phenethyl ester and piceatannol potentiated its ability to modulate HIF and NF-kB pathways and improves therapeutic outcome in experimental colitis.
TL;DR: The results indicate that albumin nano-encapsulation of CAPE/PIC not only enhances its anti-inflammatory potential but also potentiates its ability to effectively modulate inflammation related biomolecular pathways.
Journal ArticleDOI
Targeting the NLRP3 Inflammasome in Glaucoma.
Sophie Coyle,Mohammed Naeem Khan,Melody Chemaly,Breedge Callaghan,Chelsey Doyle,Colin E. Willoughby,Sarah D. Atkinson,Meredith S Gregory-Ksander,Victoria McGilligan +8 more
TL;DR: In this article, the NLRP3 inflammasome is expressed in the eye and its activation is reported in pre-clinical studies of glaucoma, which results in IL-1β processing, resulting in axon degeneration and the death of retinal ganglion cells (RGCs).