Mojtaba Mirhosseini Moghaddam

Bio: Mojtaba Mirhosseini Moghaddam is an academic researcher from Avicenna Research Institute. The author has contributed to research in topics: Indoline & Ionic liquid. The author has an hindex of 3, co-authored 6 publications receiving 52 citations. Previous affiliations of Mojtaba Mirhosseini Moghaddam include Islamic Azad University.

Alum (KAl(SO4)2·12H2O) Catalyzed Multicomponent Transformation: Simple, Efficient, and Green Route to Synthesis of Functionalized Spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐tetraones in Ionic Liquid Media

Abstract: The combination of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of alum (KAl(SO4)2·12H2O) as a catalyst for 15 min was found to be a suitable and efficient method for the synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones.

An Efficient Four‐component Synthesis of Spiro[indoline‐pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]triones

Abstract: A four-component reaction in the presence of Alum [KAl(SO4)2·12H2O] as an inexpensive and reusable catalyst using the ionic liquid as an effective green reaction media is reported.

A Novel Method for the Synthesis of Spiro[indoline‐pyrazolo[4′,3′:5,6]pyrido[2,3‐d]pyrimidine]triones by Alum as a Reusable Catalyst.

Abstract: Title compounds (IV) are efficiently synthesized through a three-component one-pot reaction using [bmim]PF6 as an effective green reaction medium.

Simple and Efficient Route to Synthesis of Functionalized Spiro(chromeno(2,3-d)pyrimidine-5,3'-indoline)- tetraones by K-10 as a Reusable Catalyst

Abstract: The reaction of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of K-10 as catalyst for 30 min was found to be a suitable and efficient method for the synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3'indoline]-tetraones. This combination was done under ionic liquid media.

Molecular diversity of spirooxindoles. Synthesis and biological activity

Abstract: Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.

Copper Ferrite Nanoparticles: An Efficient and Reusable Nanocatalyst for a Green One-Pot, Three-component Synthesis of Spirooxindoles in Water

Abstract: A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported. The features of this procedure are, the use of magnetically recoverable and reusable catalyst, mild reaction conditions, high to excellent product yields, operational simplicity, and easy workup procedures. Most importantly of all, easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction. Furthermore, the catalyst remained highly active even after 5 repeated uses.

One-pot, three-component synthesis of a library of spirooxindole-pyrimidines catalyzed by magnetic nanoparticle supported dodecyl benzenesulfonic acid in aqueous media.

Abstract: Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (γ-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones. The aqueous reaction medium, easy recovery of the catalyst using an external magnet, and high yields make the protocol sustainable and economic.

Recent applications of barbituric acid in multicomponent reactions

Abstract: Barbituric acid has been utilized in the design and synthesis of diverse types of heterocyclic and carbocyclic compounds and considered as an important building block in organic synthesis. There is a wide range of multicomponent reactions that include barbituric acid as starting material. This article aims to review the chemistry of barbituric acids employed in the design and synthesis of different types of compounds during the period from 2011 to 2015.