M
Monica Peacocke
Researcher at Columbia University
Publications - 29
Citations - 4562
Monica Peacocke is an academic researcher from Columbia University. The author has contributed to research in topics: PTEN & Cowden syndrome. The author has an hindex of 21, co-authored 29 publications receiving 4419 citations. Previous affiliations of Monica Peacocke include Tufts Medical Center.
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Journal ArticleDOI
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
Danny Liaw,Deborah J. Marsh,Jing Li,Patricia L. M. Dahia,Steven I. Wang,Z. Zheng,Shikha Bose,K. M. Call,Hui C. Tsou,Monica Peacocke,Charis Eng,Ramon Parsons +11 more
TL;DR: Mutational analysis of PTEN in CD kindreds has identified germline mutations that are predicted to disrupt the protein tyrosine/dual-specificity phosphatase domain of this gene, and implies that PTEN may play a role in organizing the relationship of different cell types within an organ during development.
Journal ArticleDOI
Mutation Spectrum and Genotype-Phenotype Analyses in Cowden Disease and Bannayan-Zonana Syndrome, Two Hamartoma Syndromes With Germline PTEN Mutation
Deborah J. Marsh,Valérie Coulon,Kathryn L. Lunetta,Philippe Rocca-Serra,Patricia L. M. Dahia,Zimu Zheng,Danny Liaw,Stacey Caron,Bernadette Duboué,Albert Y. Lin,Anne Louise Richardson,Jean Marie Bonnetblanc,Jean Marie Bressieux,Agnés Cabarrot-Moreau,Agnès Chompret,Liliane Demange,Rosalind A. Eeles,Alan M. Yahanda,Eric R. Fearon,Jean Pierre Fricker,Robert J. Gorlin,Shirley Hodgson,Susan Huson,Didier Lacombe,Frédéric Leprat,Sylvie Odent,Claude Toulouse,Olufunmilayo I. Olopade,Hagay Sobol,Sigrid Tishler,C. Geoffrey Woods,Bruce G. Robinson,H. Christian Weber,Ramon Parsons,Monica Peacocke,Michel Longy,Charis Eng,Charis Eng +37 more
TL;DR: There appeared to be an interdependent association between mutations upstream and within the PTPase core motif, the core motif containing the majority of missense mutations, and the involvement of all major organ systems (central nervous system, thyroid, breast, skin and gastrointestinal tract).
Journal ArticleDOI
Alopecia Universalis Associated with a Mutation in the Human hairless Gene
Wasim Ahmad,Muhammad Faiyaz ul Haque,Valeria Brancolini,Hui C. Tsou,Sayed ul Haque,HaMut Lam,Vincent M. Aita,Jason E. Owen,Michelle deBlaquiere,Jorge Frank,P. B. Cserhalmi-Friedman,Andrew Leask,John A. McGrath,Monica Peacocke,Mahmud Ahmad,Jurg Ott,Angela M. Christiano +16 more
TL;DR: A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19 as discussed by the authors ).
Journal Article
Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells
TL;DR: The findings reveal a dichotomy: RAR-beta transcription is down- regulated in tumor cells compared with normal human mammary epithelial cells, and up-regulated in senescence, as demonstrated by reporter gene assays.
Journal ArticleDOI
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.
James J. Choi,Igor Shendrik,Monica Peacocke,Donna M. Peehl,Ralph Buttyan,Edward F. Ikeguchi,Aaron E. Katz,Mitchell C. Benson +7 more
TL;DR: It is proposed that the accumulation of senescent epithelial cells may play a role in the development of the prostatic enlargement associated with BPH.