Monique Murawsky

TL;DR: IGF-I administration mainly results in a significant effect on the behavioral and skeletal muscle histochemical parameters of the wobbler mouse mutant, which is a model of lower motoneuron disorders with associated muscle atrophy, denervation and reinnervation.

TL;DR: N-CAM may play an important role not only in the determination of synaptic areas but also in Schwann cell-axon interactions during nerve regeneration, as suggested by results of an in vivo preparation of frog basal lamina sheaths obtained by inducing the degeneration of both nerve and muscle fibers.

TL;DR: The results suggest that cytotactin plays a primordial role in synaptogenesis, at least during nerve regeneration and reinnervation in the adult neuromuscular system.

TL;DR: In vitro, mutant astrocytes have morphological characteristics similar to those in vivo and, in particular, develop short, thick, branched processes, whereas normal mature cultures show an increased incidence of cell-cell contacts between long processes.

TL;DR: Results point to the fact that the neuron-specific expression of the human bcl2 transgene does not correct the effects of the wobbler mutation, which leads to motoneuron degeneration in early post-natal development.