M
Monique N. Vergouwe
Researcher at Maastricht University
Publications - 20
Citations - 3645
Monique N. Vergouwe is an academic researcher from Maastricht University. The author has contributed to research in topics: Inflammation & Familial hemiplegic migraine. The author has an hindex of 16, co-authored 20 publications receiving 3516 citations. Previous affiliations of Monique N. Vergouwe include Leiden University.
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Journal ArticleDOI
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
Roel A. Ophoff,Gisela M. Terwindt,Monique N. Vergouwe,Ronald van Eijk,Peter J. Oefner,Susan M.G. Hoffman,Jane Lamerdin,Harvey W. Mohrenweiser,Dennis E. Bulman,Maurizio Ferrari,Joost Haan,Dick Lindhout,Gert-Jan B. van Ommen,Marten H. Hofker,Michel D. Ferrari,Rune R. Frants +15 more
TL;DR: A brain-specific P/Q-type Ca2+ channel alpha1-subunit gene, CACNL1A4, covering 300 kb with 47 exons is characterized, revealing polymorphic variations, including a (CA)n-repeat (D19S1150), a (CAG) n-repeat in the 3'-UTR, and different types of deleterious mutations in FHM and EA-2.
Journal ArticleDOI
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
Edwin Kanters,Manolis Pasparakis,Marion J.J. Gijbels,Monique N. Vergouwe,Iris Partouns-Hendriks,Remond J.A. Fijneman,Björn E. Clausen,Irmgard Förster,Mark M. Kockx,Klaus Rajewsky,Georg Kraal,Marten H. Hofker,Menno P.J. de Winther +12 more
TL;DR: The data show that inhibition of the NF-kappaB pathway in macrophages leads to more severe atherosclerosis in mice, possibly by affecting the pro- and anti-inflammatory balance that controls the development of Atherosclerosis.
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Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions
Pieter Goossens,Marion J.J. Gijbels,Alma Zernecke,Wouter J. Eijgelaar,Monique N. Vergouwe,Ingeborg van der Made,Joris Vanderlocht,Linda Beckers,Wim A. Buurman,Mat J.A.P. Daemen,Ulrich Kalinke,Christian Weber,Christian Weber,Esther Lutgens,Esther Lutgens,Menno P.J. de Winther +15 more
TL;DR: It is demonstrated that IFNbeta enhances macrophage-endothelial cell adhesion and promotes leukocyte attraction to atherosclerosis-prone sites in mice in a chemokine-dependent manner and it is shown that type I IFN signaling is upregulated in ruptured human atherosclerotic plaques.
Journal ArticleDOI
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura.
Gisela M. Terwindt,Roel A. Ophoff,R. van Eijk,Monique N. Vergouwe,Joost Haan,Rune R. Frants,Lodewijk A. Sandkuijl,M. D. Ferrari +7 more
TL;DR: The increased allele sharing in the CACNA1A gene region on 19p13 is consistent with an important involvement of this region in migraine, especially migraine with aura.
Journal ArticleDOI
Variable clinical expression of mutations in the P/Q-type calcium channel gene in familial hemiplegic migraine
Gisela M. Terwindt,Roel A. Ophoff,Joost Haan,Monique N. Vergouwe,R. van Eijk,Rune R. Frants,M. D. Ferrari +6 more
TL;DR: It is concluded that the I1811L mutation causes both FHM and cerebellar ataxia independent of the number of CAG repeats, supporting the hypothesis that FHM is part of the migraine spectrum.