M
Mony J. de Leon
Researcher at Cornell University
Publications - 269
Citations - 32285
Mony J. de Leon is an academic researcher from Cornell University. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 80, co-authored 249 publications receiving 27784 citations. Previous affiliations of Mony J. de Leon include Rutgers University & New York University.
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Journal ArticleDOI
Mild cognitive impairment
Serge Gauthier,Barry Reisberg,Michael Zaudig,Ronald C. Petersen,Karen Ritchie,Karl Broich,Sylvie Belleville,Henry Brodaty,David A. Bennett,Howard Chertkow,Jeffrey L. Cummings,Mony J. de Leon,Howard Feldman,Mary Ganguli,Harald Hampel,Philip Scheltens,Mary C. Tierney,Peter J. Whitehouse,Bengt Winblad +18 more
TL;DR: Mild cognitive impairment can be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension.
Journal ArticleDOI
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
Frank Jessen,Frank Jessen,Rebecca E. Amariglio,Martin P.J. van Boxtel,Monique M.B. Breteler,Mathieu Ceccaldi,Gaël Chételat,Bruno Dubois,Carole Dufouil,Kathryn A. Ellis,Wiesje M. van der Flier,Lidia Glodzik,Argonde C. van Harten,Mony J. de Leon,Pauline McHugh,Michelle M. Mielke,José Luis Molinuevo,Lisa Mosconi,Ricardo S. Osorio,Audrey Perrotin,Ronald C. Petersen,Laura A. Rabin,Lorena Rami,Barry Reisberg,Dorene M. Rentz,Perminder S. Sachdev,Vincent de La Sayette,Andrew J. Saykin,Philip Scheltens,Melanie B. Shulman,Melissa J. Slavin,Reisa A. Sperling,Robert Stewart,Olga Uspenskaya,Bruno Vellas,Pieter Jelle Visser,Pieter Jelle Visser,Michael Wagner,Michael Wagner +38 more
TL;DR: Research criteria for SCD in pre‐mild cognitive impairment (MCI) are presented and a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings.
Journal ArticleDOI
Cortisol levels during human aging predict hippocampal atrophy and memory deficits.
Sonia J. Lupien,Mony J. de Leon,Susan De Santi,Antonio Convit,Chaim Tarshish,N. P. V. Nair,Mira Thakur,Bruce S. McEwen,Richard L. Hauger,Michael J. Meaney +9 more
TL;DR: It is demonstrated that aged humans with significant prolonged cortisol elevations showed reduced hippocampal volume and deficits in hippocampus-dependent memory tasks compared to normal-cortisol controls, and the degree of hippocampal atrophy correlated strongly with both the degree and current basal cortisol levels.
Journal ArticleDOI
CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
Niklas Mattsson,Henrik Zetterberg,Oskar Hansson,Niels Andreasen,Lucilla Parnetti,Michael Jonsson,Sanna-Kaisa Herukka,Wiesje M. van der Flier,Marinus A. Blankenstein,Michael Ewers,Kenneth Rich,Elmar Kaiser,Marcel M. Verbeek,Magda Tsolaki,Ezra Mulugeta,Erik Rosén,Dag Aarsland,Pieter Jelle Visser,Johannes Schröder,Jan Marcusson,Mony J. de Leon,Harald Hampel,Philip Scheltens,Tuula Pirttilä,Anders Wallin,Maria Eriksdotter Jönhagen,Lennart Minthon,Bengt Winblad,Kaj Blennow +28 more
TL;DR: This multicenter study found that CSF Abeta42, T-t Tau, and P-tau identify incipient AD with good accuracy, but less accurately than reported from single-center studies.
Journal ArticleDOI
Clearance systems in the brain—implications for Alzheimer disease
Jenna M. Tarasoff-Conway,Roxana O. Carare,Ricardo S. Osorio,Lidia Glodzik,Tracy Butler,Els Fieremans,Leon Axel,Henry Rusinek,Charles Nicholson,Berislav V. Zlokovic,Blas Frangione,Kaj Blennow,Joël Ménard,Henrik Zetterberg,Thomas Wisniewski,Mony J. de Leon +15 more
TL;DR: The clearance systems of the brain as they relate to proteins implicated in AD pathology are described, with the main focus on Aβ.