M
Moorthy P. Ponnusamy
Researcher at University of Nebraska Medical Center
Publications - 113
Citations - 4871
Moorthy P. Ponnusamy is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 36, co-authored 98 publications receiving 3695 citations. Previous affiliations of Moorthy P. Ponnusamy include Eppley Institute for Research in Cancer and Allied Diseases.
Papers
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Journal ArticleDOI
Targeting the EGFR signaling pathway in cancer therapy
Parthasarathy Seshacharyulu,Moorthy P. Ponnusamy,Dhanya Haridas,Maneesh Jain,Apar Kishor Ganti,Surinder K. Batra +5 more
TL;DR: A further understanding of the system is required to develop an effective anticancer regimen and a combination therapy that comprises an anti-EGFR and a chemotherapeutic/chemopreventive agent will exhibit a multi-pronged approach that can be developed into a highly attractive and specific molecular oriented remedy.
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Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.
Partha Mukhopadhyay,Subhankar Chakraborty,Moorthy P. Ponnusamy,Imayavaramban Lakshmanan,Maneesh Jain,Surinder K. Batra,Surinder K. Batra +6 more
TL;DR: The differential expression and functional roles of mucins in breast cancer are discussed and the potential of mucin as diagnostic and prognostic markers and as therapeutic targets in breast cancers has been discussed.
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MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells
Moorthy P. Ponnusamy,Imayavaramban Lakshmanan,Maneesh Jain,Srustidhar Das,Subhankar Chakraborty,Parama Dey,Surinder K. Batra,Surinder K. Batra +7 more
TL;DR: A novel role for MUC4 is revealed in inducing EMT through the upregulation of N-cadherin and promoting metastasis of OC cells by inducing E MT.
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Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies
María P. Torres,Moorthy P. Ponnusamy,Subhankar Chakraborty,Lynette M. Smith,Srustidhar Das,Hwyda A. Arafat,Surinder K. Batra +6 more
TL;DR: Treatment with TQ downregulated MUC4 expression through the proteasomal pathway and induced apoptosis in pancreatic cancer cells by the activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase pathways.
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MUC16 as a novel target for cancer therapy
Abhijit Aithal,Sanchita Rauth,Prakash Kshirsagar,Ashu Shah,Imayavaramban Lakshmanan,Wade M. Junker,Maneesh Jain,Moorthy P. Ponnusamy,Surinder K. Batra +8 more
TL;DR: The role of MUC16 under normal physiological conditions and during tumorigenesis is described and the role of anti-MUC16 therapy trials that are currently in the initial phases of clinical testing are discussed.