M
Moran N. Cabili
Researcher at Broad Institute
Publications - 24
Citations - 12025
Moran N. Cabili is an academic researcher from Broad Institute. The author has contributed to research in topics: Data access & RNA. The author has an hindex of 16, co-authored 23 publications receiving 10752 citations. Previous affiliations of Moran N. Cabili include Massachusetts Institute of Technology & Tel Aviv University.
Papers
More filters
Journal ArticleDOI
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Mitchell Guttman,Ido Amit,Manuel Garber,Courtney French,Michael F. Lin,David M. Feldser,Maite Huarte,Maite Huarte,Or Zuk,Bryce W. Carey,John P. Cassady,Moran N. Cabili,Rudolf Jaenisch,Tarjei S. Mikkelsen,Tyler Jacks,Nir Hacohen,Bradley E. Bernstein,Bradley E. Bernstein,Manolis Kellis,Manolis Kellis,Aviv Regev,John L. Rinn,John L. Rinn,John L. Rinn,Eric S. Lander +24 more
TL;DR: It is demonstrated that specific lincRNAs are transcriptionally regulated by key transcription factors in these processes such as p53, NFκB, Sox2, Oct4 (also known as Pou5f1) and Nanog, defining a unique collection of functional linc RNAs that are highly conserved and implicated in diverse biological processes.
Journal ArticleDOI
Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
Moran N. Cabili,Cole Trapnell,Cole Trapnell,Loyal A. Goff,Magdalena J. Koziol,Magdalena J. Koziol,Barbara Tazon-Vega,Barbara Tazon-Vega,Aviv Regev,John L. Rinn,John L. Rinn +10 more
TL;DR: It is found that lincRNA expression is strikingly tissue-specific compared with coding genes, and that l incRNAs are typically coexpressed with their neighboring genes, albeit to an extent similar to that of pairs of neighboring protein-coding genes.
Journal ArticleDOI
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: In this paper, the authors characterized the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occurs upon derivation of human iPSCs and identified numerous lincRNA whose expression is linked to pluripotency.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells
Sabine Loewer,Moran N. Cabili,Moran N. Cabili,Mitchell Guttman,Yuin-Han Loh,Kelly Thomas,Kelly Thomas,In-Hyun Park,Manuel Garber,Matthew Curran,Tamer T. Onder,Suneet Agarwal,Philip D. Manos,Philip D. Manos,Sumon Datta,Sumon Datta,Eric S. Lander,Eric S. Lander,Thorsten M. Schlaeger,Thorsten M. Schlaeger,George Q. Daley,John L. Rinn,John L. Rinn +22 more
TL;DR: It is found that one such lincRNA (lincRNA-RoR) modulates reprogramming, thus providing a first demonstration for critical functions of lincRNAs in the derivation of pluripotent stem cells.
Journal ArticleDOI
Network-based prediction of human tissue-specific metabolism
TL;DR: This work presents a computational method that successfully describes the tissue specificity of human metabolism on a large scale by integrating tissue-specific gene- and protein-expression data with an existing comprehensive reconstruction of the global human metabolic network.