M
Moreno Cocchietto
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 45
Citations - 3254
Moreno Cocchietto is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: NAMI-A & In vivo. The author has an hindex of 26, co-authored 45 publications receiving 3090 citations. Previous affiliations of Moreno Cocchietto include University of Trieste.
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Journal ArticleDOI
In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes
Claudine Scolaro,Alberta Bergamo,Laura Brescacin,R. Delfino,Moreno Cocchietto,Gábor Laurenczy,Tilmann J. Geldbach,Gianni Sava,Paul J. Dyson +8 more
TL;DR: Results show that these ruthenium(II)-arene complexes can reduce the growth of lung metastases in CBA mice bearing the MCa mammary carcinoma in the absence of a corresponding action at the site of primary tumor growth.
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A review on usnic acid, an interesting natural compound.
TL;DR: This review summarises the most relevant studies on usnic acid, focusing on a number of biological activities in different fields, and finds the (+)-usnic acid enantiomer appears to be selective against Streptococcus mutans without inducing perturbing side effects on the oral saprophyte flora.
Journal Article
Dual Action of NAMI-A in Inhibition of Solid Tumor Metastasis Selective Targeting of Metastatic Cells and Binding to Collagen
Gianni Sava,Sonia Zorzet,Claudia Turrin,Francesca Vita,MariaRosa Soranzo,Giuliano Zabucchi,Moreno Cocchietto,Alberta Bergamo,Stefano DiGiovine,Gabriella Pezzoni,Luigi Sartor,Spiridione Garbisa +11 more
TL;DR: Evidence is provided that NAMI-A's effect is based on the selective sensitivity of the metastasis cell, as compared with other tumor cells, and to show that lungs represent a privileged site for the antimetastatic effects.
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Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A
Gianni Sava,Alberta Bergamo,Sonia Zorzet,Barbara Gava,Claudia Casarsa,Moreno Cocchietto,A. Furlani,Vito Scarcia,Barbara Serli,Elisabetta Iengo,Enzo Alessio,Giovanni Mestroni +11 more
TL;DR: The data show that NAMI-A, although undergoing a series of chemical modifications, maintains its antimetastatic activity in a broad range of experimental conditions.
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Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds
Claudine Scolaro,Tilmann J. Geldbach,Sébastien Rochat,Antoine Dorcier,Christian Gossens,Alberta Bergamo,Moreno Cocchietto,Ivano Tavernelli,Gianni Sava,Ursula Rothlisberger,Paul J. Dyson +10 more
TL;DR: The reactivity of the functionalized RAPTA compounds with a 14-mer oligonucleotide (established by mass spectrometry) has been rationalized by DFT calculations, which indicate that environmental factors are important.