Moritz Zaiss

TL;DR: An overview of some of the latest methodological developments in human ultra-high field MRI/MRS as well as associated clinical and scientific applications is presented, with emphasis on techniques that particularly benefit from the changing physical characteristics at high magnetic fields.

TL;DR: This review considers analytical solutions of the Bloch–McConnell (BM) equation system which enable deep insight and theoretical description of CEST and the equivalent off-resonant spinlock (SL) experiments and derive and discuss proposed theoretical treatments in detail to understand the influence of saturation parameters on the acquired Z-spectrum and how the different effects interfere and can be isolated in MR Z-Spectroscopy.

TL;DR: A spillover correction is of special interest for clinical static field strengths and protons resonating near the water peak, as it forms the motivation for simple metrics that correct the CEST signal.

TL;DR: An analytical solution of the Bloch–McConnell equations that describes the magnetization of coupled spin populations under radiofrequency irradiation is derived and it is shown that existing theoretical treatments for CEST are special cases of this approach.

TL;DR: After correction, the CEST effect of amides and Nuclear-Overhauser-mediated saturation transfer does not show significant contrast between contrast enhancing tumor regions and normal tissue, whereas NOE drops significantly in the tumor area, suggesting that previous CEST approaches might not have shown pure CEST effects, but rather water relaxation shine-through effects.