M
Motowo Tomita
Researcher at Showa University
Publications - 117
Citations - 11842
Motowo Tomita is an academic researcher from Showa University. The author has contributed to research in topics: Peptide sequence & Gene. The author has an hindex of 41, co-authored 117 publications receiving 11459 citations. Previous affiliations of Motowo Tomita include Keio University.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma.
TL;DR: Its adipocyte-specific expression suggests that GBP28 may function as an endogenous factor involved in lipid catabolism and storage or whole body metabolism, and appears to belong to a family of proteins possessing a collagen-like domain through which they form homo-trimers, which further combine to make oligomeric complexes.
Journal ArticleDOI
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the japanese population
Kazuo Hara,Philippe Boutin,Yasumichi Mori,Kazuyuki Tobe,Christian Dina,Kazuki Yasuda,Toshimasa Yamauchi,Shuichi Otabe,Terumasa Okada,Kazuhiro Eto,Hiroko Kadowaki,Ryoko Hagura,Yasuo Akanuma,Yoshio Yazaki,Ryozo Nagai,Matsuo Taniyama,Koichi Matsubara,Madoka Yoda,Yasuko Nakano,Satoshi Kimura,Motowo Tomita,Chikako Ito,Philippe Froguel,Takashi Kadowaki +23 more
TL;DR: Evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes is presented, and the observation that adiponECTin improves insulin sensitivity in animal models is concluded.
Journal ArticleDOI
Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population.
Yukihiro Yamamoto,Hiroshi Hirose,Ikuo Saito,Motowo Tomita,Matsuo Taniyama,Koichi Matsubara,Yasunori Okazaki,Tatsuya Ishii,Kanako Nishikai,Takao Saruta +9 more
TL;DR: It is suggested that the serum adiponectin level is negatively correlated with HOMA-IR and positively correlated with HDL-cholesterol, independent of age, sex and BMI, in the Japanese population.
Journal ArticleDOI
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
Jorge Ghiso,E. Matsubara,Alexei R. Koudinov,Nam Ho Choi-Miura,Motowo Tomita,Thomas Wisniewski,B. Frangione +6 more
TL;DR: Using direct binding experiments, this work isolated and characterized an 80 kDa circulating protein that specifically interacts with a synthetic peptide identical with A beta, and retrieved soluble A beta from cerebrospinal fluid, indicating that the interaction occurs in vivo.