M
Motoyuki Sugai
Researcher at Hiroshima University
Publications - 197
Citations - 10004
Motoyuki Sugai is an academic researcher from Hiroshima University. The author has contributed to research in topics: Staphylococcus aureus & Gene. The author has an hindex of 55, co-authored 170 publications receiving 9188 citations. Previous affiliations of Motoyuki Sugai include Kawasaki Medical School & Juntendo University.
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Journal ArticleDOI
A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus
Florian H. Pilsczek,Davide Salina,Karen K. H. Poon,Candace Fahey,Bryan G. Yipp,Christopher D. Sibley,Stephen M. Robbins,Francis H. Y. Green,Michael G. Surette,Motoyuki Sugai,M. Gabriela Bowden,Muzaffar Hussain,Kunyan Zhang,Paul Kubes +13 more
TL;DR: A new mechanism of NET release that is very rapid and contributes to trapping and killing of S. aureus through a novel process of NET formation that did not require neutrophil lysis or even breach of the plasma membrane.
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Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease
Kazuhisa Ouhara,Hitoshi Komatsuzawa,Sakuo Yamada,Hideki Shiba,Tamaki Fujiwara,Masaru Ohara,Koji Sayama,Koji Hashimoto,Hidemi Kurihara,Motoyuki Sugai +9 more
TL;DR: These results indicate that beta-defensins and LL37 have versatile antibacterial activity against oral bacteria.
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Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37
Sho Tokumaru,Koji Sayama,Yuji Shirakata,Hitoshi Komatsuzawa,Kazuhisa Ouhara,Yasushi Hanakawa,Yoko Yahata,Xiuju Dai,Mikiko Tohyama,Hiroshi Nagai,Lujun Yang,Shigeki Higashiyama,Akihiko Yoshimura,Motoyuki Sugai,Koji Hashimoto +14 more
TL;DR: It is suggested that LL-37 closes skin wounds by the induction of keratinocyte migration via heparin-binding-EGF-mediated transactivation of EGFR, and SOCS1/Jak2 binding protein or SOCS3/CIS3 negatively regulate this migration.
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A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.
Tadahiro Oshida,Motoyuki Sugai,Hitoshi Komatsuzawa,Yeong-Man Hong,Hidekazu Suginaka,Alexander Tomasz +5 more
TL;DR: The Tn551 insertion site of the autolysis-deficient Staphylococcus aureus mutant RUSAL2 was cloned and used to identify the autologic gene atl in the parent strain, RN450, which is a bifunctional protein that has an amidase domain and an endo-beta-N-acetylglucosaminidase domain.
Journal ArticleDOI
Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, β-Defensins and CAP18, Expressed by Human Keratinocytes
Kazushige Midorikawa,Kazuhisa Ouhara,Hitoshi Komatsuzawa,Toshihisa Kawai,Sakuo Yamada,Tamaki Fujiwara,Kenshi Yamazaki,Koji Sayama,Martin A. Taubman,Hidemi Kurihara,Koji Hashimoto,Motoyuki Sugai +11 more
TL;DR: Of several genes associated with methicillin resistance, inactivation of the fmtC gene in MRSA strain COL increased susceptibility to the antimicrobial effect mediated by hBD3 or CAP18.