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Moudhi Abdullah Al-Mutlaq

Other affiliations: National Guard Health Affairs
Bio: Moudhi Abdullah Al-Mutlaq is an academic researcher from King Saud University. The author has contributed to research in topics: Cancer & Vitamin D and neurology. The author has an hindex of 3, co-authored 6 publications receiving 58 citations. Previous affiliations of Moudhi Abdullah Al-Mutlaq include National Guard Health Affairs.

Papers
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Journal ArticleDOI
TL;DR: Increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys, and measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathion S-transferase was conducted.
Abstract: Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.

87 citations

Journal ArticleDOI
TL;DR: The results revealed that the type of Chaetomorpha sp.
Abstract: Seaweeds are a group of marine multicellular algae; the presence of antioxidant phytochemical constituents in Seaweed Chaetomorpha sp. extracts has received attention for their role in the prevention of human diseases. This study explores the phytochemical constituents, antioxidant, and anticancer properties of the Cladophoraceae, Chaetomorpha sp. Energy dispersive x-ray spectroscopy (EDX), and Gas chromatography-mass spectrometry (GC/MS) were performed to study the chemical structure and chemical formula. Different concentrations of ethanol and aqueous extracts of Chaetomorpha were used to estimate antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and total flavonoid, phenolic, and tannins content assays. Anti-tumor activity against breast cancer cell lines (MCF-7 and MDA-MB-231) was assessed by 3-(4,5-Dimethylthiazol-2-cyl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. The EDX analysis indicated the presence of oxygen, silicon, and calcium as dominant elements. Antioxidant assays indicated that the ethanol extracts of Chaetomorpha consisted of a total of 189.14 ± 0.99 mg QE/g flavonoid content, 21.92 ± 0.43 mg GAE/g phenolic content and 21.81 ± 0.04 mg GAE/g tannins content. The DPPH radical scavenging assay exhibited higher antioxidant activity IC50 (9.41 ± 0.54 mg/mL) in the ethanol extract. Moreover, it showed high anticancer activity by growth inhibition in the MDA-MB-231 breast cancer cell line and low IC50 (225.18 ± 0.61 µg/mL). GC/MS analysis revealed the presence of Dichloracetic acid (DCA) as the active antitumor constituent of Chaetomorpha sp.; other anticancer compounds identified were Oximes and L-α-Terpinol. The results revealed that the type of Chaetomorpha sp. studied here possesses very unique and novel constituents and active potent antitumor chemical constituents and it can act as a promising antioxidant and anticancer agent for future applications in pharmaceutical industries.

59 citations

Journal ArticleDOI
27 May 2020
TL;DR: Vitamin D3 and curcumin can be a promising natural therapy for the treatment of Alzheimer disease, which resulted in the better recovery of neuronal cells from Aβ1-42 treatment.
Abstract: Background:Alzheimer disease is a progressive neurodegenerative disease, affecting a very high proportion of the aging population. Several studies have demonstrated that one of the main contributor...

17 citations

Journal ArticleDOI
15 Apr 2021
TL;DR: In this paper, the link between the dysregulation of classical renin-angiotensin system and counter-regulatory RAS activities in COVID-19 patients with cardiovascular metabolic diseases is investigated.
Abstract: In the current coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme-2 (ACE-2) receptor for cell entry leading to ACE-2 dysfunction and downregulation which disturbs the balance between classical and counter-regulatory renin-angiotensin system (RAS) in favor of classical RAS. RAS dysregulation is one of the major characteristics of several cardiovascular diseases, thus adjustment of this system is the main therapeutic target. RAS inhibitors - particularly angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) - are commonly used for treatment of hypertension and cardiovascular disease. Patients with cardiovascular diseases are the group most commonly seen amongst those with COVID-19 comorbidity. At the beginning of this pandemic, a dilemma occurred regarding the use of ACEIs and ARBs potentially aggravating cardiovascular and pulmonary dysfunction in COVID-19 patients. Urgent clinical trials from different countries and hospitals reported that there is no association between RAS inhibitor treatment and COVID-19 infection or comorbidity complication. Nevertheless, the disturbance of the RAS system that is associated with COVID-19 infection and the potential treatment targeting this area has yet to be resolved. In this review, the link between the dysregulation of classical RAS and counter-regulatory RAS activities in COVID-19 patients with cardiovascular metabolic diseases is investigated. In addition, the latest findings based on ACEIs and ARBs administration and ACE-2 availability in relation to COVID-19 which may provide a better understanding of RAS contribution to COVID-19 pathology is discussed as it is of the utmost importance amid the current pandemic.

10 citations

Journal ArticleDOI
TL;DR: In this paper, the effect of local Renin Angiotensin System (RAS) in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised.
Abstract: The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it is expressed locally in almost all of the body’s tissues. In this review, current knowledge on the effect of local RAS in the common types of cancer such as breast, lung, liver, prostate and skin cancer is summarised. The mechanisms by which RAS components could increase or decrease cancer activity are also discussed. In addition to the former, this review explores how the administration of AT1R blockers and ACE inhibitors drugs intervene with cancer therapy and contribute to the outcomes of cancer.

8 citations


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Journal ArticleDOI
TL;DR: This review focuses on the extraction, purification, and future applications of seaweedphenolic compounds based on the bioactive properties described in the literature and intends to provide a comprehensive insight into the phenolic compounds in seaweed.
Abstract: Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyphenol class is the phlorotannins, which are specifically synthesized by brown seaweeds, but there are other polyphenolic compounds, such as bromophenols, flavonoids, phenolic terpenoids, and mycosporine-like amino acids. The compounds already discovered and characterized demonstrate a full range of bioactivities and potential future applications in various industrial sectors. This review focuses on the extraction, purification, and future applications of seaweed phenolic compounds based on the bioactive properties described in the literature. It also intends to provide a comprehensive insight into the phenolic compounds in seaweed.

194 citations

Journal ArticleDOI
TL;DR: This review addresses different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors and their potential efficacy and safety as a cancer lessening agents.
Abstract: Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents.

99 citations

Journal ArticleDOI
TL;DR: Pro-longevity therapies should aim to maintain the levels of both NAD+ and NADPH in aging tissues, because NADP+ is exclusively synthesized from NAD+ by cytoplasmic and mitochondrial NAD+ kinases, and a decline in the cytopsized or mitochondrial NADPH pool may also contribute to the aging process.
Abstract: The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects against redox stress by providing reducing equivalents to antioxidants such as glutathione and thioredoxin. NADPH levels decline with aging in several tissues, but whether this is a major driving force for the aging process has not been well established. Global or neural overexpression of several cytoplasmic enzymes that synthesize NADPH have been shown to extend lifespan in model organisms such as Drosophila suggesting a positive relationship between cytoplasmic NADPH levels and longevity. Mitochondrial NADPH plays an important role in the protection against redox stress and cell death and mitochondrial NADPH-utilizing thioredoxin reductase 2 levels correlate with species longevity in cells from rodents and primates. Mitochondrial NADPH shuttles allow for some NADPH flux between the cytoplasm and mitochondria. Since a decline of nicotinamide adenine dinucleotide (NAD+) is linked with aging and because NADP+ is exclusively synthesized from NAD+ by cytoplasmic and mitochondrial NAD+ kinases, a decline in the cytoplasmic or mitochondrial NADPH pool may also contribute to the aging process. Therefore pro-longevity therapies should aim to maintain the levels of both NAD+ and NADPH in aging tissues.

97 citations

Journal ArticleDOI
05 Jun 2020-Symmetry
TL;DR: The results obtained indicates that 90 ppm of graphene oxide nanoparticles and 10% n-butanol in Nigella sativa biodiesel are comparable with diesel fuel.
Abstract: The present investigation uses a blend of Nigella sativa biodiesel, diesel, n-butanol, and graphene oxide nanoparticles to enhance the performance, combustion and symmetric characteristics and to reduce the emissions from the diesel engine of a modified common rail direct injection (CRDI). A symmetric toroidal-type combustion chamber and a six-hole solenoid fuel injector were used in the current investigation. The research aimed to study the effect of two fuel additives, n-butanol and synthesized asymmetric graphene oxide nanoparticles, in improving the fuel properties of Nigella sativa biodiesel (NSME25). The concentration of n-butanol (10%) was kept constant, and asymmetric graphene oxide nano-additive and sodium dodecyl benzene sulphonate (SDBS) surfactant were added to n-butanol and NSME25 in the form of nanofluid in varying proportions. The nanofluids were prepared using a probe sonication process to prevent nanoparticles from agglomerating in the base fluid. The process was repeated for biodiesel, n-butanol and nanofluid, and four different stable and symmetric nanofuel mixtures were prepared by varying the graphene oxide (30, 60, 90 and 120 ppm). The nanofuel blend NSME25B10GO90 displayed an enhancement in the brake thermal efficiency (BTE) and a reduction in brake-specific fuel consumption (BSFC) at maximum load due to high catalytic activity and the enhanced microexplosion phenomenon developed by graphene oxide nanoparticles. The heat release rate (HRR), in-cylinder temperature increased, while exhaust gas temperature (EGT) decreased. Smoke, hydrocarbon (HC), carbon monoxide (CO2) and carbon monoxide (CO) emissions also fell, in a trade-off with marginally increased NOx, for all nanofuel blends, compared with Nigella sativa biodiesel. The results obtained indicates that 90 ppm of graphene oxide nanoparticles and 10% n-butanol in Nigella sativa biodiesel are comparable with diesel fuel.

96 citations

Journal ArticleDOI
18 Dec 2020-Animal
TL;DR: The bioactive bromoform found in the red seaweed Asparagopsis taxiformis has been identified as an agent that can reduce enteric CH4 production from livestock significantly, however, sustainable supply of this seaweed is a problem and there are some concerns over its sustainable production.
Abstract: Seaweeds contain a myriad of nutrients and bioactives including proteins, carbohydrates and to a lesser extent lipids as well as small molecules including peptides, saponins, alkaloids and pigments. The bioactive bromoform found in the red seaweed Asparagopsis taxiformis has been identified as an agent that can reduce enteric CH4 production from livestock significantly. However, sustainable supply of this seaweed is a problem and there are some concerns over its sustainable production and potential negative environmental impacts on the ozone layer and the health impacts of bromoform. This review collates information on seaweeds and seaweed bioactives and the documented impact on CH4 emissions in vitro and in vivo as well as associated environmental, economic and health impacts.

65 citations