M
Mourad Sahbatou
Researcher at Council on Education for Public Health
Publications - 31
Citations - 8576
Mourad Sahbatou is an academic researcher from Council on Education for Public Health. The author has contributed to research in topics: Population & Inbreeding. The author has an hindex of 16, co-authored 30 publications receiving 8025 citations. Previous affiliations of Mourad Sahbatou include Paris Diderot University & Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain.
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Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis
Slaheddine Marrakchi,Philippe Guigue,Blair R. Renshaw,Anne Puel,Xue-Yuan Pei,Sylvie Fraitag,Jihen Zribi,Elodie Bal,Céline Cluzeau,Maya Chrabieh,Jennifer E. Towne,Jason Douangpanya,Christian Pons,Sourour Mansour,Valérie Serre,Hafedh Makni,Nadia Mahfoudh,Faiza Fakhfakh,Christine Bodemer,Josué Feingold,Smail Hadj-Rabia,Michel Favre,Emmanuelle Génin,Mourad Sahbatou,Arnold Munnich,Jean-Laurent Casanova,John E. Sims,Hamida Turki,Hervé Bachelez,Asma Smahi +29 more
TL;DR: Aberrant interleukin-36Ra structure and function lead to unregulated secretion of inflammatory cytokines and generalized pustular psoriasis.
Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Rafal Kustra,Rafal Kustra,Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Sylviane Olschwang,Theodore Chiang,Edgar Crowdy,Vincent Ferretti,Philippe Laflamme,Saravanan Sundararajan,Stéphanie Roumy,Jean François Olivier,Frederick Robidoux,Robert Sladek,Alexandre Montpetit,Peter T. Campbell,Stéphane Bézieau,Anne Marie O'Shea,George Zogopoulos,Michelle Cotterchio,Michelle Cotterchio,Polly A. Newcomb,John R. McLaughlin,John R. McLaughlin,Ban Younghusband,Roger C. Green,Jane Green,Mary Porteous,Harry Campbell,Hélène Blanché,Mourad Sahbatou,Emmanuel Tubacher,Catherine Bonaïti-Pellié,Bruno Buecher,Elio Riboli,Sébastien Küry,Stephen J. Chanock,John D. Potter,Gilles Thomas,Steven Gallinger,Steven Gallinger,Thomas J. Hudson,Thomas J. Hudson,Malcolm G. Dunlop +48 more
TL;DR: Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.
Journal ArticleDOI
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype.
Hilde Brems,Magdalena Chmara,Magdalena Chmara,Mourad Sahbatou,Ellen Denayer,Koji Taniguchi,Reiko Kato,Riet Somers,Riet Somers,Ludwine Messiaen,Sofie De Schepper,Jean Pierre Fryns,Jan Cools,Jan Cools,Peter Marynen,Peter Marynen,Gilles Thomas,Akihiko Yoshimura,Eric Legius +18 more
TL;DR: G germline loss-of-function mutations in SPRED1 in a newly identified autosomal dominant human disorder are reported, the first report of mutations in the SPRY (SPROUTY)/SPRED family of genes in human disease.
Journal ArticleDOI
Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.
Suzanne Lesage,Valérie Drouet,Elisa Majounie,Vincent Deramecourt,Maxime Jacoupy,Aude Nicolas,Florence Cormier-Dequaire,Sidi Mohamed Hassoun,Claire Pujol,Sorana Ciura,Zoi Erpapazoglou,T.S. Usenko,Claude-Alain Maurage,Mourad Sahbatou,Stefan Liebau,Jinhui Ding,Başar Bilgiç,Murat Emre,Nihan Erginel-Unaltuna,Gamze Guven,François Tison,Christine Tranchant,Marie Vidailhet,Jean-Christophe Corvol,Paul Krack,Anne-Louise Leutenegger,Mike A. Nalls,Dena G. Hernandez,Peter Heutink,J. Raphael Gibbs,John Hardy,Nicholas W. Wood,Thomas Gasser,Alexandra Durr,Jean-François Deleuze,Meriem Tazir,Alain Destée,Ebba Lohmann,Edor Kabashi,Andrew B. Singleton,Olga Corti,Alexis Brice +41 more
TL;DR: This work suggests that loss of function of VPS13C is a cause of autosomal-recessive early-onset parkinsonism with a distinctive phenotype of rapid and severe progression.