M
Mourad Toporsian
Researcher at Beth Israel Deaconess Medical Center
Publications - 22
Citations - 2692
Mourad Toporsian is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Endoglin & Endothelium. The author has an hindex of 14, co-authored 22 publications receiving 2498 citations. Previous affiliations of Mourad Toporsian include University of South Alabama & McGill University Health Centre.
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Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal ArticleDOI
A Role for Endoglin in Coupling eNOS Activity and Regulating Vascular Tone Revealed in Hereditary Hemorrhagic Telangiectasia
Mourad Toporsian,Robert Gros,Mohammed G. Kabir,Sonia Vera,Karuthapillai Govindaraju,David H. Eidelman,Mansoor Husain,Michelle Letarte +7 more
TL;DR: It is reported that resistance arteries from Eng+/− mice display an eNOS-dependent enhancement in endothelium-dependent dilatation and impairment in the myogenic response, despite reduced eN OS levels, and that the use of antioxidants may provide a novel therapeutic modality.
Journal ArticleDOI
Reduced angiogenic responses in adult endoglin heterozygous mice
Mirjana Jerkic,Alicia Rodríguez-Barbero,Marta Prieto,Mourad Toporsian,Miguel Pericacho,Juan V. Rivas-Elena,Juana Obreo,Angela Wang,Fernando Pérez-Barriocanal,Miguel Arévalo,Carmelo Bernabeu,Michelle Letarte,José M. López-Novoa +12 more
TL;DR: It is suggested that a normal level of endoglin is required for full angiogenic activity in adult Endoglin heterozygous mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1.
Journal ArticleDOI
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant.
Michael E. Ward,Mourad Toporsian,Jeremy A. Scott,Hwee Teoh,Vasanthi Govindaraju,Adrian Quan,Avraham D. Wener,Guilin Wang,Siân C. Bevan,Derek C. Newton,Philip A. Marsden +10 more
TL;DR: A novel human nN OS promoter is revealed that confers the ability to rapidly upregulate nNOS expression in response to hypoxia with a functionally significant effect on vascular smooth muscle contraction.
Journal ArticleDOI
Downregulation of Endothelial Nitric Oxide Synthase in Rat Aorta After Prolonged Hypoxia In Vivo
Mourad Toporsian,Karuthapillai Govindaraju,Mohammed Nagi,David H. Eidelman,Gaétan Thibault,Michael E. Ward +5 more
TL;DR: Ipaired endothelial NO release may handicap the vascular responses that defend vital organ function during hypoxia, and this study results suggest that endothelial nitric oxide synthase expression in the systemic circulation is affected.