M
Moustapha Kassem
Researcher at University of Southern Denmark
Publications - 384
Citations - 24743
Moustapha Kassem is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 79, co-authored 366 publications receiving 22407 citations. Previous affiliations of Moustapha Kassem include Mayo Clinic & King Saud University.
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Journal ArticleDOI
Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells.
TL;DR: In conclusion, aging is associated with decreased proliferative capacity of osteoprogenitor cells, suggesting that decreased osteoblastic cell number, and not function, leads to age-related decrease in bone formation.
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Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells.
Janne L. Simonsen,Cecilia Rosada,Cecilia Rosada,Nedime Serakinci,J. Justesen,J. Justesen,Karin Stenderup,Karin Stenderup,Suresh I. S. Rattan,Thomas G. Jensen,Moustapha Kassem,Moustapha Kassem +11 more
TL;DR: It is suggested that ectopic expression of telomerase in hMSCs prevents senescence-associated impairment of osteoblast functions.
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Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis.
TL;DR: The hypothesis that with aging and in osteoporosis an enhancedadipogenesis is observed in the bone marrow and that these changes areversely correlated to decreased trabecular bone volume is supported.
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Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation
Irina Kratchmarova,Blagoy Blagoev,Blagoy Blagoev,Mandana Haack-Sørensen,Mandana Haack-Sørensen,Moustapha Kassem,Moustapha Kassem,Matthias Mann,Matthias Mann +8 more
TL;DR: It is found that the differentiation of human mesenchymal stem cells into bone-forming cells is stimulated by epidermal growth factor but not platelet-derived growth factor (PDGF).
Journal ArticleDOI
Playing with bone and fat.
TL;DR: A review of the recent literature exploring the mechanisms underlying differentiation events within the bone marrow microenvironment and their implications relevant to osteoporosis and regenerative medicine.