Muhammad Adeel

Bio: Muhammad Adeel is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Copolymer & Polymerization. The author has an hindex of 11, co-authored 26 publications receiving 726 citations. Previous affiliations of Muhammad Adeel include University of Antwerp.

Multifunctional metal–organic frameworks-based biocatalytic platforms: recent developments and future prospects

Abstract: In recent years, metal–organic frameworks (MOFs) have received accelerating research attention as a versatile carrier and promising bio-immobilization support materials for enzyme immobilization. This is particularly due to their extraordinary structural properties and multi-functionalities, such as surface area, high porosity, tunable topography, crystallinity, electronic and optical properties, thermal/chemical stability and multiple affinities (hydrophobicity and hydrophilicity). Excellent biocatalytic performance, improved stability and repeatability, high loading ability, and greater accessibility to catalytic sites are the key attributes associated with the use of novel MOF–enzyme bio-composites. This review discusses the recent developments in the use of MOFs as immobilization support materials as a platform to engineer different kinds of enzymes with requisite functionalities for biocatalysis applications in different sectors of the modern world. The second part of the review mainly focuses on MOFs-assisted immobilization strategies including surface immobilization, covalent binding, cage inclusion and in situ MOF formation and enzyme immobilization to develop enzyme–MOF bio-catalytic system. The characteristic properties rendering MOFs as interesting matrices for bio-immobilization are also presented following applications of MOFs-immobilized bio-catalyst for catalysis, sensing and detection, and protein digestion. Lastly, the review is wrapped up with conclusions and an outlook in terms of upcoming challenges and prospects for their scale-up applications.

Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures

Abstract: Molecular self-assembly is the spontaneous association of molecules under equilibrium conditions into stable, structurally well-defined aggregates joined by noncovalent bonds. Molecular self-assembly is ubiquitous in biological systems and underlies the formation of a wide variety of complex biological structures. Understanding self-assembly and the associated noncovalent interactions that connect complementary interacting molecular surfaces in biological aggregates is a central concern in structural biochemistry. Self-assembly is also emerging as a new strategy in chemical synthesis, with the potential of generating nonbiological structures with dimensions of 1 to 10(2) nanometers (with molecular weights of 10(4) to 10(10) daltons). Structures in the upper part of this range of sizes are presently inaccessible through chemical synthesis, and the ability to prepare them would open a route to structures comparable in size (and perhaps complementary in function) to those that can be prepared by microlithography and other techniques of microfabrication.

Metal-Organic Frameworks for the Removal of Emerging Organic Contaminants in Water.

Abstract: Water is essential in all aspects of life, being the defining characteristic of our planet and even our body. Regrettably, water pollution is increasingly becoming a challenge due to novel anthropogenic pollutants. Of particular concern are emerging organic contaminants (EOCs), the term used not only to cover newly developed compounds but also compounds newly discovered as contaminants in the environment. Aside from anthropogenic contamination, higher temperature and more extreme and less predictable weather conditions are projected to affect water availability and distribution. Therefore, wastewater treatment has to become a valuable water resource and its reuse is an important issue that must be carried out efficiently. Among the novel technologies considered in water remediation processes, metal-organic frameworks (MOFs) are regarded as promising materials for the elimination of EOCs since they present many properties that commend them in water treatment: large surface area, easy functionalizable cavities, some are stable in water, and synthesized at large scale, etc. This review highlights the advances in the use of MOFs in the elimination (adsorption and/or degradation) of EOCs from water, classifying them by the nature of the contaminant.

Metal-Organic Frameworks for Biomedical Applications.

Abstract: Metal-organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during the past decades. Due to the unique features of diverse compositions, facile synthesis, easy surface functionalization, high surface areas, adjustable porosity, and tunable biocompatibility, MOFs have been widely used in hydrogen/methane storage, catalysis, biological imaging and sensing, drug delivery, desalination, gas separation, magnetic and electronic devices, nonlinear optics, water vapor capture, etc. Notably, with the rapid development of synthetic methods and surface functionalization strategies, smart MOF-based nanocomposites with advanced bio-related properties have been designed and fabricated to meet the growing demands of MOF materials for biomedical applications. This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis. The prospects and challenges in the field of MOF-based biomedical materials are also discussed.