Muhammad Zaki Hidayatullah Fadlullah

TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.

TL;DR: It is shown that a specific polymorphism in the PPL gene could confer resistance to erlotinib and other EGFR inhibitors and further work to evaluate these as biomarkers of response is warranted.

TL;DR: The functional utility of GENIPAC was demonstrated with some of the genomic alterations that are commonly reported in HNC, such as TP53, EGFR, CCND1, and PIK3CA, and it was shown that these genomic alterations as reported in The Cancer Genome Atlas database were recapitulated in the HNC cell lines inGENIPAC.

TL;DR: A novel automated cell detection and counting software, QuickCount® (QC), designed for rapid quantification of cells, equipped with real-time preview while optimizing the parameters for accurate cell count and needs minimum hands-on time.

TL;DR: A high-throughput workflow that utilizes benchtop next-generation sequencing and in-house bioinformatics tools to link the laboratory processes to increase the verification throughput of somatic rearrangements and showed that next- generation sequencing methods are comparable to conventional Sanger sequencing.