M
Mukul K. Basu
Researcher at Indian Institute of Chemical Biology
Publications - 79
Citations - 1871
Mukul K. Basu is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: Liposome & Drug carrier. The author has an hindex of 26, co-authored 79 publications receiving 1784 citations. Previous affiliations of Mukul K. Basu include Albert Einstein College of Medicine & Northwestern University.
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Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms
TL;DR: The antileishmanial property of amarogentin, a secoiridoid glycoside isolated from the Indian medicinal plant Swertia chirata, was examined in a hamster model of experimental leishmaniasis and its therapeutic efficacy was evaluated.
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Targeting of Liposomal Andrographolide to L.donovani-Infected Macrophages in Vivo
TL;DR: Mannosylated drug-loaded liposome-treated animals showed a normal blood picture and splenic tissue histoarchitecture when compared with those treated with free drug or regular liposomal drug, and a drug-vehicle formulation may be considered for clinical trials.
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Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems.
TL;DR: Because of its appreciable efficacy in destroying intracellular parasites as well as non-hepatotoxic and non-nephrotoxic nature, harmine, in the vesicular forms, may be considered for clinical application in humans.
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Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes
TL;DR: The mannose-grafted liposomes were adjudged to be the best in lowering of spleen parasite load in comparison with those bearing glucose or galactose and the therapeutic efficacy of pentamidine isethionate was found to be better than that of its methoxy derivative, although the latter seemed to be less toxic than the pentamIDS itself.
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Macrophage specific drug delivery in experimental leishmaniasis.
Mukul K. Basu,Sanchaita Lala +1 more
TL;DR: The niosomes, being cheaper, less toxic, biodegradable and non-immunogenic, were considered for sometime as suitable alternatives to liposomes as drug carriers and turned out to be the best and thus may be projected for effective use in the clinics.