Muralidhararao Bagadi

TL;DR: Using both shotgun and 2D‐imaging lipidomics analysis, a hitherto unrecognized alteration in phospholipid profiles in NSCLC is uncovered, which may have important biological implications and may have significant potential for biomarker development.

TL;DR: It is revealed that several commonly used drugs restore ciliogenesis in cancer cells, and warrant further investigation of their antineoplastic properties.

TL;DR: The p53 network to phospholipid metabolism is expanded and a new molecular pathway connecting p53 to AKT signaling is uncovered, which contributes to the p53-mediated control of cell survival.

TL;DR: In this article, the authors used quantitative mass spectrometry to define the "lipidome" in prostate tumors with matched benign tissues, independent unmatched tissues, and primary prostate explants cultured with the clinical AR antagonist enzalutamide (n = 43).

TL;DR: This first characterization of the prostate cancer lipidome in clinical tissues revealed enhanced fatty acid synthesis, elongation and desaturation as tumor-defining features, with potential for therapeutic targeting.